ATP-binding cassette (ABC) efflux transporters are expressed in the human placenta where they are thought to help protect the fetus from xenobiotics. To evaluate models for analysis of ABC transporter function and regulation in the placenta, we have characterized the expression and activity of multidrug resistance (MDR) 1/P glycoprotein (Pgp), MDR3/Pgp, breast cancer resistance protein (BCRP), ...

In Wallace Stevens’ poem “The anecdote of the jar”, the narrator has put a jar on a Tennessee hilltop, with apparently dramatic results. The jar, we are told, took dominion everywhere, imposed order on the slovenly wilderness, and forced the wilderness to surround the hill on which it sat. Before the jar, it seems there were no human objects in the wilderness. And natural features like hills an...

This document shows the instances that were used for the CHeSC 2011 competition. These instances are available within the JAR file containing the HyFlex software framework[2] version used for the competition. The first four domains were released before the competition as training domains with 10 instances each. There are now 12 instances in each because we added two hidden instances for the com...

In this work, we investigate the bidirectional mutual interactions (BMI) between users’ activities and user-user relationships on social networking sites. We analyze and study the fundamental mechanism that drives the characteristics and dynamics of BMI is the underlying social influence. We make an attempt at a unified probabilistic approach, called joint activity and relation (JAR), for model...

Eigenmannia, a genus of weakly electric fish, exhibits a specialized behavior known as the jamming avoidance response (JAR). The JAR results in a categorical difference between Eigenmannia that are in groups of conspecifics and those that are alone. Fish in groups exhibit the JAR behavior and thereby experience ongoing, global synchronous 20- to 50-Hz electrosensory oscillations, whereas solita...

Differences in the mechanism of ethylene emanation of Ficus sycomorus L. during various stages of the fruit development were investigated by enclosing the figs in jars. Two distinct patterns of ethylene emanation were found. Pattern a. in stages not capable of ripening, neither spontaneously nor as a result of physiological treatment (nonripening stages A and C), ethylene concentration in the j...

Paleoparasitology is the application of conventional or molecular investigative techniques to archeological samples in order to reveal parasitic infection patterns among past populations. Although pioneering studies already have reported key paleoparasitological findings around the world, the same sorts of studies had not, until very recently, been conducted in sufficient numbers in Korea. Mumm...

The role of transforming growth factor-alpha (TGF-alpha)-epidermal growth factor receptor (EGFR) interactions in regulating benign and malignant trophoblast proliferation were examined. Benign cytotrophoblast (CT) demonstrated mitogenic stimulation in response to TGF-alpha; BeWo and JAr choriocarcinoma cell lines failed to respond. EGFR levels in BeWo and JAr were determined by enzyme linked im...

There is an urgent need to develop optimized experimental models to examine human implantation. These studies aimed to (i) establish a human endometrium-like three-dimensional (3D) culture system, and (ii) examine the attachment of trophoblast-like Jar spheroids to the culture. In the present work, 3D endometrial cultures were constructed with fibrin-agarose as matrix scaffold, and using epithe...