Molecular dynamics simulations of miRNA–chitosan complexes are performed with various compositions chitosan (GlcN, GlcN(+) and GlcNAc). DP FA showed a significant influence on the formation molecular complexes.

Enhancing oral bioavailability of hydrophilic drugs by encapsulation in lipid-based nanocarriers, including Solid Lipid Nanoparticles (SLN), has been well documented. In this work, high molecular weight heparin was “insolubilized” an “ion-paring” approach, forming Chitosan/Heparin Polyelectrolyte Complexes (PEC) to promote its SLN. Hybrid PEC-SLN, heparin-loaded SLN (H-SLN) as naked PEC were pr...

Nanochitosan is a nanoparticle of chitosan with size between 100-400 nm. has higher antibacterial ability than ordinary chitosan. The manufacture into nanochitosan can be done by ionic gelation method, namely the complexation polyelectrolyte positively charged and negatively sodium tripolyphosphate. morphology in form whole sphere typical functional groups such as amine, hydroxyl carboxyl group...

This article reports the investigation of mechanical properties of alginate-chitosan microcapsules and the relation to protein delivery. For microscale compression testing, a system based on a microelectromechanical systems (MEMS) capacitive force sensor was developed. The bulk microfabricated capacitive force sensors are capable of resolving forces up to 110 microN with a resolution of 33.2 nN...

Aluminum sulfate (alum), ferrous sulfate, ferric chloride and ferric chloro-sulfate were commonly used as coagulants. However, a possible link of Alzheimer’s disease with conventional aluminium based coagulants has become an issue in wastewater treatment. Hence, special attention has shift towards using biodegradable polymer, chitosan in treatment, which are more environmental friendly. Moreove...

Coupling of electrostatic complexation with conformational transition is rather general in protein/polyelectrolyte interaction and has important implications in many biological processes and practical applications. This work studied the electrostatic complexation between κ-carrageenan (κ-car) and type B gelatin, and analyzed the effects of the conformational ordering of κ-car induced upon cooli...

Polyelectrolyte complexes present new opportunities for self-assembled soft matter. Factors determining whether the phase of the complex is solid or liquid remain unclear. Ionic polypeptides enable examination of the effects of stereochemistry on complex formation. Here we demonstrate that chirality determines the state of polyelectrolyte complexes, formed from mixing dilute solutions of opposi...

Two-ply composite membranes with separation layers from chitosan and sulfoethylcellulose were developed on a microporous support based on poly(diphenylsulfone-N-phenylphthalimide) and investigated by use of X-ray diffraction and scanning electron microscopy methods. The pervaporation properties of the membranes were studied for the separation of aqueous alcohol (ethanol, propan-2-ol) mixtures o...

The cationic charged chitosan and the weak polyacid poly(ethylene-alt-maleic acid) are used to build polyelectrolyte multilayers (PEMs). To study rotational dynamics of polymer backbone in swollen state PEMs using electron paramagnetic resonance spectroscopy, a nitroxide spin-label is covalently attached polyacid. It found that spectra with even number layers show superposition two spectral com...