Progress in understanding the roles of kainate receptors (KARs) in synaptic integration, synaptic networks, and higher brain function has been hampered by the lack of selective pharmacological tools. We have found that UBP310 and related willardiine derivatives, previously characterized as selective GluK1 and GluK3 KAR antagonists, block postsynaptic KARs at hippocampal mossy fiber (MF) CA3 syn...

Kainate receptors (KARs) play an important role in synaptic physiology, plasticity, and pathological phenomena such as epilepsy. However, the physiological implications for neuronal networks of the distinct expression patterns of KAR subunits are unknown. Using KAR knock-out mice, we show that subunits glutamate receptor (GluR) 5 and GluR6 play distinct roles in kainate-induced gamma oscillatio...

E-commerce sites currently provide poor access to information and knowledge. Accessibility is a key issue, both for selling individual products and services, and for selling the concept of e-commerce ahead of other modes of commerce. This report uses the concept of Features, Advantages and Benefits (FAB) to define knowledge-level accessibility requirements (KAR). The KAR criteria are applied in...

Two decades have passed since the first report of the cloning of a kainate-type glutamate receptor (KAR) subunit. The intervening years have seen a rapid growth in our understanding of the biophysical properties and function of KARs in the brain. This research has led to an appreciation that KARs play very distinct roles at synapses relative to other members of the glutamate-gated ion channel r...

................................................................................................................................ 1 1 Literature Review ............................................................................................................... 2 1.1 Kainate Receptors ........................................................................................................ 2 1.1...

A tanulmány a Sokszínű Kar multidiszciplináris konferenciasorozat negyedik rendezvényének prezentációit mutatja be kivonatolt módon. konferencián olyan témakörök kaptak helyet, mint kábítószerek, gyermekbarát kihallgatási módszerek, rendészeti együttműködés, bűnügyi helyszínelés, magánbiztonság és sportrendezvények biztosítása, az innováció, kritikus infrastruktúra, valamint mesterséges intelli...