The effects of thiourea injection on scale development were studied in New Hampshire Red x White Leghorn Cross chick embryos. Normal morphogenesis and keratinization of scales were significantly delayed in thioureatreated specimens. Subsequent thyroxine injection resulted in normal or even precocious scale development. The thyroid hormone responsiveness of scale development is discussed in rela...

Disseminated superficial actinic porokeratosis (DSAP) is a disorder of abnormal keratinization for which there no standard treatment. Treatment modalities that have traditionally been utilized with varying success include ablative therapies, topical pharmacologic treatments, surgical excision, and retinoids. The underlying pathophysiology DSAP secondary to genetic mutations in the mevalonate bi...

Repeated epilation (Er) is a radiation-induced, autosomal, incomplete dominant mutation in mice which is expressed in heterozygotes but is lethal in the homozygous condition. Many effects of the mutation occur in skin: the epidermis in Er/Er mice is adhesive (oral and nasal orifices fuse, limbs adhere to the body wall), hyperplastic, and fails to undergo terminal differentiation. Skin from feta...

TMEM45A gene encodes an initially uncharacterized predicted transmembrane protein. We previously showed that this gene is highly expressed in keratinocytes where its expression correlates with keratinization, suggesting a role in normal epidermal physiology. To test this hypothesis, we generated TMEM45A knockout mice and found that these mice develop without any evident phenotype. The morpholog...

Lorenzo Alibardi (2003) Immunocytochemistry and keratinization in the epidermis of crocodilians. Zoological Studies 42(2): 346-356. The distributions of alpha and beta keratins, filaggrin and loricrine are described in crocodilian epidermis by immunocytochemistry and electron microscopy. Many layers of beta keratin cells are produced in the outer surface of the scutes, but in the hinge region b...

Acne vulgaris is a common skin condition encountered in specialties outside of dermatology, including obstetrics and gynecology. The pathophysiology acne complex includes disruption the cutaneous microbiome, abnormal keratinization, inflammation, hormonal influences. Various topical systemic treatment modalities target each component pathophysiology. Clinically, can be broken down into noninfla...

The aim of the study: to examine relationship between morphological diversity non-small cell lung cancer and frequency lymph node metastasis in groups patients with different epithelial conditions bronchi adjacent tumor. Material methods. Surgical specimens from 90 cancer, who were treated Thoracoabdominal Department Of Research Institute Oncology Tomsk National Medical Center period 2009 2017 ...

Sir, Porokeratotic eccrine ostial and dermal duct naevus (PEODDN) is a rare disorder of keratinization with eccrine involvement that histologically presents a cornoid lamella exclusively associated with eccrine ostia and the underlying sweat ducts (1). It is an expression of genetic mosaicism (2) and is characterized by asymptomatic grouped keratotic papules and plaques with a linear distributi...