Using immunofluorescence techniques, we analyzed the distribution of glycoproteins in normal and keratoconus corneas of humans. Laminin, bullous pemphigoid antigen, fibronectin, and fibrin/fibrinogen were all found in the epithelial basement membrane of normal corneas. Keratoconus corneas produced similar results, except that staining for fibrin/fibrinogen was weak. Fibrin/fibrinogen was absent...

Keratoconus associated with myelinated retinal nerve fibers is not frequent and the relationship between the two pathologies is difficult to explain, therefore studies and further investigation are required. The etiology of each condition may suggest the role of genetic factors. Follow-up is important to evaluate the progression of keratoconus and myelination. Here we describe the unusual coexi...

purpose: comparing the optical coherence tomography (oct) pachymetry patterns in keratoconus suspect and normal people methods: thirty-two keratoconus suspects and 36 healthy eyes were selected within the age range of 20-30 yrs. their pachymetry pattern was obtained through oct visante in the minimum thickness spot, upper and lower corneal difference (i-s), lower temporal, and upper nasal thick...

PURPOSE The mRNA levels of antioxidant enzymes, matrix metalloproteinases, cathepsin V/L2, and tissue inhibitor of matrix metalloproteinases (TIMPs) were determined in keratoconus and normal corneas. Protein levels or enzyme activities were analyzed when RNA levels were different. METHODS A total of 25 physiologic (normal) and 32 keratoconus corneas were studied. mRNAs were analyzed by semiqu...

PURPOSE To characterize corneal structural changes in keratoconus using a new morphogeometric approach and to evaluate its potential diagnostic ability. METHODS Comparative study including 464 eyes of 464 patients (age, 16 and 72 years) divided into two groups: control group (143 healthy eyes) and keratoconus group (321 keratoconus eyes). Topographic information (Sirius, CSO, Italy) was proce...

Objectives To describe the past 20 years' correction modalities for keratoconus and their visual outcomes and possible complications. Methods A review of the published literature related to the visual outcomes and possible complications in the context of keratoconus management using nonsurgical procedures for the last 20 years (glasses and contact lenses) was performed. Original articles that...

PURPOSE We determined if the Impact of Vision Impairment (IVI) is a valid questionnaire to measure the vision-related quality of life (VRQoL) in keratoconus patients, and investigated if the VRQoL varied with disease severity in this sample. METHODS WE RECRUITED 160 CONSECUTIVE BILATERAL KERATOCONUS PATIENTS (MEAN AGE 23.3 YEARS, 63% MALE) FROM AN INDIAN TERTIARY EYE CARE CENTER. PARTICIPANTS...

PURPOSE To screen for keratoconus and potential associated risk factors in a tertiary student population sample. POPULATION AND METHODS This cross sectional study included 1234 students attending An-Najah National University (Nablus, West Bank, Palestine), that were randomly selected from a total of 20,000 university students. 634 (51.3%) student participants responded by completing a self-ad...

PURPOSE To look for segregation of Visual System Homeobox 1 (VSX1) mutations in family members of a patient with keratoconus. METHODS Our initial molecular genetic studies conducted to identify the role of VSX1 in the causation of keratoconus had identified a novel mutation in one patient. He later presented to the clinic affected with vernal kerato conjunctivitis (VKC) accompanied by his bro...

PURPOSE To evaluate the sensitivity, specificity, and test accuracy of corneal biomechanical metrics and anterior segment data in differentiating keratoconus from healthy corneas. METHODS Comparative case series. Patients with and without keratoconus (gender and age-matched) were submitted for complete eye examinations including corneal hysteresis (CH) and corneal resistance factor (CRF) as m...