the relation between serum osmolality, glucose, sodium, bicarbonate, arterial ph, bun and level of consciousness was studied in 189 patients with diabetic ketoacidosis (dka). there was much overlap between all laboratory values among various groups, even when there was a statistically significant difference. to find a better predictor, we defined a new factor as serum osmolality/arterial ph. th...

OBJECTIVES Diabetic ketoacidosis is a recurrent problem in the emergency room that requires prompt and effective treatment. Usually, it may be associated with an increase in triglyceride levels, exposing the patient to the risk of pancreatitis. METHODS We report the case of a 38-year-old female patient with diabetic ketoacidosis and severe hypertriglyceridemia (triglycerides: 11.758 mg/dL). ...

The contribution of the exocrine pancreas to hyperamylasemia in diabetic ketoacidosis was investigated by measuring total amylase, salivary and pancreatic isoamylases, cathodic trypsin-like immunoreactivity, and pancreatic lipase in 12 consecutive patients recovering from diabetic ketoacidosis. Hyperamylasemia was present in six of the patients [50%; expected incidence: 21.1-78.9% (95% confiden...

Sodium glucose co-transporter (SGLT-2) inhibitor is a relatively new medication used to treat diabetes. At present, the Food and Drug Administration (FDA) has only approved three medications (canagliflozin, dapagliflozin and empagliflozin) in this drug class for the management of Type 2 diabetes. In May 2015, the FDA issued a warning of ketoacidosis with use of this drug class. Risk factors for...

Ketoacidosis is a potential complication of type 1 diabetes. Severe ketoacidosis with a blood pH below 7.0 is only rarely seen in other diseases.Three weeks after delivery, a young woman was admitted because of tachypnoe and tachycardia. Blood gas analysis showed a severe metabolic acidosis with a high anion gap. Further workup revealed the presence of ketone bodies in the urine with normal blo...

CONTEXT Atypical antipsychotic agents are associated with diabetes mellitus and pancreatitis. Aripiprazole, a new antipsychotic, has never been implicated to cause either diabetes mellitus or pancreatitis. We present a patient who developed diabetes mellitus after being started on aripiprazole. CASE REPORT A 33 year-old male with schizophrenia presented with fatigue, dyspepsia and epigastric ...

Ketonaemia is well documented as a consequence of prolonged starvation, acute alcoholism, and uncontrolled diabetes mellitus. However, its occurrence in acute pancreatitis has not been described. In this report, three patients who manifested ketoacidosis at the time of presentation of acute pancreatitis are described. In none of these patients could ketoacidosis be attributed to any of the well...

We describe three cases of pneumomediastinum associated with diabetic ketoacidosis and give reasons why these disorders may coexist more frequentiy than heretofore realized. The pathogenesis of pneumomediastinum in such patients remains obscure. Previous authors have considered the pneumomediastinum to be a consequence of vomiting or hyperpnea accompanying diabetic ketoacidosis, but we point ou...

The effects of chronic metabolic acidosis, alkalosis and alloxan-induced ketoacidosis on G6PD activity of rat kidney, liver and erythrocytes were studied. Metabolic acidosis significantly increased the activity of kidney enzyme (55%) but decreased the liver (43%) and erythrocyte (38%) enzyme activities. Alkalosis did not make a significant change in the kidney or liver enzyme activity but ...

The present study investigate a QTc interval prolongation in diagnosed cases of Diabetic Ketoacidosis with reference to electrolyte imbalances. ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are dangerous manifestations diabetes mellitus representing two extremes the spectrum uncontrolled diabetic state. DKA accounts for 14 percentages all hospital admissions among diabetics 16 d...