In the title compound, [Sn(C(6)H(11))(3)(C(15)H(14)NO(2))], the Sn(IV) atom adopts a distorted tetra-hedral SnOC(3) arrangement. The dihedral angle between the benzene rings in the mefanamic acid mol-ecule is 82.16 (17)° and intra-molecular N-H⋯O and C-H⋯O hydrogen bonds help to establish the conformation. Two of the cyclo-hexyl rings are disordered over two sets of sites with equal occupancies.

ABSTRACT. The present study describes synthesis of some new luminol derivatives, which might play an important role in biological active agents. These synthesized compounds are functionalized based on (LM) with different carboxylic drugs such as mefenamic acid, ibuprofen, diclofenac sodium, and ampicillin). Synthesis processes was conducted by converting group the investigated into acid chlorid...

Hepatocytes and liver microsomes are considered to be useful for investigating drug metabolism catalyzed mainly via glucuronidation. However, there have been few reports comparing the glucuronidation inhibition potentials of drug in hepatocytes to those in liver microsomes. 3'-Azido-3'-deoxythymidine (AZT, zidovudine) glucuronidation (AZTG) is the major metabolic pathway for AZT. In this study,...

Purpose To screen for and characterize compounds that protect corneal endothelial cells against unfolded protein response (UPR) and oxidative stress. Methods Bovine corneal endothelial cells (BCECs) were treated for 48 hours with 640 compounds from a Food and Drug Administration (FDA)-approved drug library and then challenged with thapsigargin or H2O2 to induce UPR or oxidative stress, respec...

BACKGROUND Office hysteroscopy with endometrial biopsy is usually the first investigation for abnormal uterine bleeding and other uterine diseases. AIMS To evaluate the effect of oral drotaverine with mefenamic acid on pain perception during hysteroscopy and endometrial biopsy and to compare it with that of paracervical block using 1% lignocaine and with that of intravenous sedation using dia...