introduction: acute renal failure is a common consequence of sepisis due to concurrent renal ischaemia. the role of nitric oxide (no) in endotoxaemia and in ischaemic injury in the kidney is not well defined. material and methods: in this study we have used an animal model of sepsis induced by injection of bacterial lipopolysaccharide (lps) in the rat and measured renal nitric oxide by x-band e...

Bisphenol A is a very high volume chemical with estrogenic activity that is used in a wide range of products, including medical equipment such as hemodialyzers. Virtually all people have measurable amounts of BPA, since this chemical readily leaches out of products that contain it. BPA is associated with a wide range of diseases because it alters programming of the expression of genes that are ...

In the early 1990s live kidney donation regained popularity to meet the demand of kidney transplantation. Significant developments in the field of live kidney donation have established live donation as the potential prime source of kidney transplants in the future. Nowadays management focuses on logistic and immunological innovations, and improvements in care of the live donor. However, a flawl...

The effective treatment for renal failure dates from the invention during World War 11 of the first workable artificial kidney by Dr Wilhelm Kolff in Klampen in occupied Holland. He demonstrated that it is possible to remove waste products of metabolism from the bloodstream, thereby cleansing the body when the kidneys have failed. Moreover, he showed that clinical improvement followed rapidly. ...

The first artificial kidney to be used in the British Isles was one of Kolff's original four which he donated to Hammersmith Hospital soon after the end of World War 2. It was used for a while in the late 1 940's 1 but was then relegated to the basement when enthusiasm for the conservative treatment of acute renal failure was at its height. To my chagrin it is now displayed in a museum in the U...