the cytotoxic chloroform fraction of euphorbia aellenii afforded two cycloartane type triterpenes — cycloart-25-en-3,24-diol (1) and 24-methylene-cycloartan-3-ol (2) — for the first time from this plant. preparation of cycloartane derivatives, 3, 24-o-diacetyl-cycloart-25-en as compound 3 and 3-o-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. the ...

conclusions despite the fact that abnormalities in p53 and p27kip1 may be involved in the development of oscc, their clinical significance in the studied population seems limited. further investigation on the combined p53/p27kip1 expression may be helpful in predicting the biologic behavior of this tumor. results p53 and p27kip1 expression were found in 28.57% (8 positive versus 20 negative) an...

Long-term potentiation (LTP) is a biological process of learning and memory after a high-frequency train of electrical stimulations. By binding of brain-derived neurotrophic factor (BDNF) to Tropomyosin receptor kinase B (TrKB) receptors in postsynaptic neurons, tyrosine kinase Fyn is bound to these receptors and hereby plays a mediating role to binding and activation of N-methyl-D-aspartic aci...

considering that mapk (mitogen- activated protein kinase) signaling pathway has an important role in the progression of inflammatory cytokine secretion in type 2 diabetes mellitus (t2dm), we have recently investigated the reported genetic polymorphism from genome wide association study in map3k1 (mitogen-activated protein kinase kinase kinase 1) in diabetes as an important member of mapk signal...

Hallervorden-Spatz syndrome is a disorder characterized by dystonia, parkinsonism, and iron accumulation in the brain. The disease is caused by mutations in gene encoding pantothenate kinase 2 (PANK2) and patients have pantothenate kinase-associated neurodegeneration. We present an 8-year-old boy with progressive muscle dystonia, neuroregression, frequent fall and multiple injur...

To explore the mechanism of microRNA-125a reversing resistance laryngeal cancer stem cells to cisplatin from mitochondrial autophagy. The human carcinoma cell line Hep-2 was purchased Shanghai Bioleaf Biotechnology Co., Ltd. expression messenger RNA in each group analyzed by reverse transcription-polymerase chain reaction. migration and invasion ability evaluated Transwell assay. Cell apoptosis...

objective(s):  the role of the apoptosis repressor with caspase recruitment domain (arc) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of endothelin-1 induced cardiac hypertrophy remains unknown. the present study discusses the inhibitory role of arc against endothelin–induced hypertrophy. results:in present study endothelin treated card...

introduction: increased oxidative stress is widely accepted to be a factor in the development and progression of alzheimer’s disease. triazine derivatives possess a wide range of pharmacological activities including anti-oxidative and anti-in.ammatory actions. in this study, we aimed to investigate the possible protective effect of 3-thioethyl-5,6-dimethoxyphenyl-1,2,4-triazine (tedmt) on h2o2-...

background: the mitogen-activated protein kinase (mapk) pathway is one of the major signaling pathways that transmit intracellular signals initiated by extracellular stimuli to the nucleus. the stress-activated protein kinase (sapk)/c-jun nh2-terminal kinase is a subfamily of map kinases implicated in cytokine and stress responses. objective: in this study, we have examined total and phosphoryl...

Accumulation of gene changes and chromosomal instability in response to cellular DNA damage lead to cancer. DNA damage induces cell cycle checkpoints pathways. Checkpoints regulate DNA replication and cell cycle progression, chromatin restructuring, and apoptosis. Checkpoint kinase 2 (chk2) is activated in response to DNA lesions. ATM phosphorylate chk2. The activated Chk2 kinase can phosphoryl...