BACKGROUND Both endoplasmic reticulum (ER) stress, a fundamental cell response associated with stress-initiated unfolded protein response (UPR), and loss of Klotho, an anti-aging hormone linked to NF-κB-induced inflammation, occur in chronic metabolic diseases such as obesity and type 2 diabetes. We investigated if the loss of Klotho is causally linked to increased ER stress. METHODS We treat...

BACKGROUND/AIMS Klotho gene, a new anti-aging gene, is mainly expressed in the kidney tubules. Several studies have found the relationship between klotho and emergence and development of renal diseases. This study set out to explore the role of fosinopril (Fos) and valsartan (Val) on klotho expression induced by angiotensin II (Ang II) in rat renal tubular epithelial cells (NRK-52E). METHODS ...

Chronic kidney disease has an indirect effect on global disorder and death by raising the risks of morbidityand mortality . This study included (60) patient diagnosed chronic renal failure; it also (25)healthy subjects as control In population age ranged from (14-65 years) old who visited Al-BasrahTeaching Hospital in Basrah throughout period October 2020 to February 2021. Enzyme-LinkedImmunoso...

 In recent years, researchers have been looking for genes whose products can directly affect the aging process. Among these, the anti-aging protein klotho has attracted much attention. This single transmembrane protein is expressed in the renal tissues, parathyroid gland and choroid network of the brain and acts as a co-receptor for Fibroblast Growth Factor FGF. In this way, it contributes to c...

The Klotho gene codes for a type-i membrane protein that exists in two forms—as a transmembrane protein and as a secreted protein. Particularly the secreted form of Klotho suppresses oxidative stress and growth factor signaling and regulates ion channels and transporters. it was reported that Klotho overexpression suppresses insulin/iGF-1 signaling. This signaling pathway was indicated as a cen...

OBJECTIVES: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments w...

Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the progression of Alzheimer's disease (AD). The natural phthalide Ligustilide (LIG) has been demonstrated to protect against aging- and amyloid-β (Aβ)-induced brain dysfunction in animal models. The present study is to inves...

The activity of respiratory chain enzymes in a rat's masseter muscle changes as the animal ages; however, there is little information about the RNA transcript levels of mitochondrial enzymes in klotho mutant mice as they age. We measured the activities of NADH-ferricyanide oxidoreductase and NADH-O2 oxidoreductase, and the RNA transcript levels of NADH dehydrogenase, the mitochondrial isoform o...

BACKGROUND/AIMS Carbon monoxide (CO) interferes with cytochrome-dependent cellular functions and acts as gaseous transmitter. CO is released from CO-releasing molecules (CORM) including tricarbonyl-dichlororuthenium (II) dimer (CORM-2), molecules considered for the treatment of several disorders including vascular dysfunction, inflammation, tissue ischemia and organ rejection. Cytochrome P450-s...

A model animal showing spontaneous onset is a useful tool for investigating the mechanism of disease. Here, I would like to introduce two aging model animals expected to be useful for neuroscience research: the senescence-accelerated mouse (SAM) and the klotho mouse. The SAM was developed as a mouse showing a senescence-related phenotype such as a short lifespan or rapid advancement of senescen...