Epigenetic modifications such as histone deacetylation are commonly related to tumor development and histone deacetylase (HDAC) inhibitors have been shown to be potential drugs for cancer treatment. In the present study, we investigated the effects of a novel HDAC inhibitor, Ky-2, on oral squamous carcinoma cells in vitro. Cell viability was significantly reduced by treatment with Ky-2 at 25 nM...

Lactose intolerance is frequently encountered in children with persistent diarrhoea (PD). Selection of an appropriate milk-based formulation is a major management problem in the developing world. In a consecutive series of studies, we evaluated the role of feeding a traditional rice-lentil (khitchri) diet alone (KY) or in combination with either soy formula (KY-Soy) a dilute buffalo milk (KY-B)...

this paper presents a control strategy for fuel cell/energy storage power generation system during voltage sag conditions. the hybrid dc power sources are connected to grid using power electronic converters include dc-dc converter and grid connected voltage source inverter. the power from hybrid power sources is controlled during voltage sag by designing of control strategy for dc-dc converter....

in this paper, a novel approach for control of the dc-dc buck converter in high-power and low-voltage applications is proposed. designed method is developed according to state feedback linearization based controller , which is able to stabilize output voltage in a wide range of operation. it is clear that in high-power applications, parasitic elements of the converter may become comparable with...

active filters have proven to be more effective than passive techniques to improve power quality and to solve harmonic and power factor problems due to nonlinear loads. this paper proposes a control scheme based on the instantaneous active and reactive power. the inverter of this active filter is a three-phase, two-level converter. space vector technique is used as modulators and pattern genera...

A non-isolated DC/DC converter with high transfer gain is proposed in this paper. The presented converter consists of the switched inductor and three-level converters. The DC/DC power converter is three-level boost converter to convert the output voltage of the DC source into two voltage sources. The main advantages of DC/DC converter are using low voltage semiconductors and high gain voltage. ...

Úvod: DneĹĄnĂ­ trh nabĂ­zĂ­ uĹživatelĹŻm velkĂŠ mnoĹžstvĂ­ manuĂĄlnĂ­ch zubnĂ­ch kartáčkĹŻ lĂĄkavĂ˝ch barev, odliĹĄnĂ˝ch designĹŻ hlaviček, rukojetĂ­, zastřiĹženĂ­ a měkkosti vlĂĄken, ale i rozličnĂ˝ch cen. Je vĹĄak drahĂ˝, ekologickĂ˝ či pestrobarevnĂ˝ kartáček kvalitnĂ­ nepoĹĄkozuje nĂĄs? KvalitnĂ­ je definovĂĄn jako kartáček, kterĂ˝ svĂ˝mi vlĂĄkny dĂĄsně ani tvrdĂŠ zubnĂ­ tkĂĄnÄ...

Highlights • New data reveal for the first time a history of the last ∼33.7 ky of uplift of Samosir. • Minimum uplift rates were high (4.9 cm/year) for the first 11.2 ky but diminished after that to <1 cm/year for the last 22.5 ky. • Numerical modeling suggests that rebound of remnant magma augmented by deep recharge appears to be the most likely driver for uplift. • Detumescence makes a neglig...

We have characterized the developmental expression pattern of the Caenorhabditis elegans homologue of the mouse ky gene. The Ky protein has a putative key function in muscle development and has homologues in invertebrates, fungi and a cyanobacterium. The C. elegans Ky homologue gene has been named ltd-1 for LIM and transglutaminase domains gene. The LTD-1::GFP construct is expressed in developi...