Autoradiographic studies on the synthesis of DNA in heart muscle cells of younger normal rats after administration of 3H-thymidine were made. The labeling index of heart muscle cells in 4 hours was 8.30% on the 2nd day of life and it gradually declined to 0.15•Ž in 3 weeks. The labeling index of interstitial cells was 9.8% on the second day of life and it similarly declined to 1.0% in 3 weeks. ...

Leukemic cells were obtained from the bone marrow or peripheral blood of patients with acute myelocytic leukemia or one of its variants. The tritiated thymidine labeling index of the leukemic cells and the suicide index of the cells that produce clusters in vitro were compared. The suicide index was 5 times greater than the labeling index (S.E.) [54 +/- 8% versus 12 +/- 3%], demonstrating the p...

LetG=(V ,E) be a graph, a vertex labeling f : V → Z2 induces an edge labeling f ∗ : E → Z2 defined by f ∗(xy)=f (x)+f (y) for each xy ∈ E. For each i ∈ Z2, define vf (i)=|f−1(i)| and ef (i)=|f ∗−1(i)|. We call f friendly if |vf (1)− vf (0)| 1. The full friendly index set of G is the set of all possible values of ef (1)− ef (0), where f is friendly. In this note, we study the full friendly index...

Recent evidence has suggested that the induction of DNA synthesis by nongenotoxic chemical carcinogens plays an important role in the formation of cancer. The present study examined the effect of a nongenotoxic carcinogen, phenobarbital, (PB) on the induction of DNA synthesis in preneoplastic foci and adenomas in B6C3F1 mice. Male mice were treated with diethylnitrosamine at 30 days of age. Aft...

Bromodeoxyuridine, an analogue of thymidine, can be detected by means of monoclonal antibodies and utilized as a marker of the S-phase of the cell cycle. In vitro immunohistochemical application of the BrdU/anti-BrdU-MAb method permits a quantitative assessment of the proliferative activity of a tissue as well as the direct location of the actively replicating cells in histological sections. In...

normal 0 false false false microsoftinternetexplorer4 background : despite well-described histopathologic criteria, the distinction of spontaneous abortion from hydatidiform mole and complete hydatidiform mole from partial hydatidiform mole remains a problem because of interobserver and intraobserver variability. the aim of this study was to evaluate the value of two immunohistochemical markers...

The cytokinetics of a naturally occurring hyperplastic disease of the colon in mice were determined by autora diography and compared to kinetic changes seen by others in nonneoplastic and neoplastic colonic disease. Cell cycle parameters were determined using the fraction-labeled mi tosis method. Labeling index, labeling pattern, and migra tion rates were also evaluated. During colonic hyperpla...