The US04 trial was a multicenter, open-label, single arm trial of deferasirox monotherapy (30-40 mg/kg/day) for 18 months. Cardiac iron response was bimodal with improvements observed in patients with mild to moderate initial somatic iron stores; relationship of cardiac response to labile plasma iron is now presented. Labile plasma iron was measured at baseline, six months, and 12 months. In pa...

background: k+ channel toxins are essential tools for the first purifications, analysis of subunit structures and brain localization of voltage-gated k+ (kv) channels. the effects of a lot of toxins on kv are not fully known. methods: using whole-cell patch clamping technique the action of a series of toxins on kv3.4 current in rat liver cells with expressed kv3.4 channels (rle) cloned cells wa...

Labile iron, i.e. iron that is weakly bound and is relatively unrestricted in its redox activity, has been implicated in both the pathogenesis as well as treatment of cancer. Two cancer treatments where labile iron may contribute to their mechanism of action are pharmacological ascorbate and ionizing radiation (IR). Pharmacological ascorbate has been shown to have tumor-specific toxic effects d...