A 66-year-old man presented with a slowly enlarging, nontender left orbital mass of 2 months' duration. CT and MRI showed a left lacrimal gland mass with enhancement and internal irregularity of cystic structures. Histopathologic analysis of the biopsy specimen revealed a squamous cell carcinoma arising from an epithelium-lined cyst. The patient underwent left orbital exenteration followed by r...

PURPOSE MRL/MpJ-+/+ (MRL/+) and MRL/MpJ-lpr/lpr (MRL/lpr) mice show spontaneous development of a T-cell-driven lacrimal gland inflammation that is a model for Sjögren syndrome. The lacrimal gland lesions in these mice were evaluated by quantitative RT-PCR for selected cytokine mRNA for the relative contributions of T-helper (Th)1 versus Th2 immune responses and by RT-PCR and immunohistochemistr...

PURPOSE To determine whether prolactin receptor is essential for normal development and function of the lacrimal gland and whether hyperprolactinemia can alter lacrimal development. METHODS Lacrimal gland morphology and function were examined in two genetic mouse models of prolactin action: a prolactin receptor knockout model that is devoid of prolactin action and a transgenic model of hyperp...

Purpose: The aim of this work was to demonswate that the exorbital rat lacrimal gland was a site of synthesis of some growth factors of the EGF family (EGF, HB-EGF, TGFa) and their receptor, namely the EGF receptor ,FGFP\ \ --. . . , Methods: Male Sprague Dawley rats were used in these experhnents. RTPCR and Northern-Blot analysis of the lacrimal gland mRNA population were pe~fotmcd to study th...

Myxomas are rare neoplasms of mesenchymal origin. Cases of conjunctival, corneal, and orbital myxomas have been reported in the literature; however, to the best of our knowledge, there is no report of a lacrimal gland myxoma. We report a case of an orbital myxoma involving the lacrimal gland and its management.

BACKGROUND Amiodarone is a drug that is used for treatment of cardiac arrhythmia after cardiac ischemia. This drug as beta blocker decreases arrhythmia rate but it has many side effects on different tissues. Since there are rare reports about changes of lacrimal glands, this research has been carried out to study the morphological and ultrastructural changes of lacrimal gland cells after amioda...

Epithelial tumors of the lacrimal gland are histologically similar to salivary gland tumors. Here we report on a rare case of mucoepidermoid carcinoma (MEC) in a 73‑year-old man with a swelling of the left lacrimal gland. The tumor had a microscopic appearance consistent with a classical low-grade MEC of the lacrimal gland. There were no signs of ...

Purpose: The aim of this work was to demonswate that the exorbital rat lacrimal gland was a site of synthesis of some growth factors of the EGF family (EGF, HB-EGF, TGFa) and their receptor, namely the EGF receptor ,FGFP\ \ --. . . , Methods: Male Sprague Dawley rats were used in these experhnents. RTPCR and Northern-Blot analysis of the lacrimal gland mRNA population were pe~fotmcd to study th...

Primary ductal adenocarcinoma is a rare subtype of adenocarcinoma. Literature review showed 13 cases of primary ductal adenocarcinoma of the lacrimal gland. We report a case of primary ductal adenocarcinoma of the lacrimal gland and review of literature highlighting its clinical presentation, histopathology including immunochemistry and overall outcome.

Background: Although surgical intervention is the therapeutic mainstay for epiphora secondary to nasolacrimal obstruction, offlabel injection of onabotulinumtoxinA (BTX-A) into the lacrimal gland has emerged as an effective, minimally invasive alternative. We investigated the structural and molecular changes within the lacrimal gland of the New Zealand White rabbit model, following intraglandul...