Letter to the EditorCould an intrarenal Cori cycle participate in urinary concentrating mechanism?Lise BankirLise BankirCentre de Recherche des Cordeliers, Institut National la Santé et Médicale, Sorbonne Université, Université Paris, FranceCentre Scientifique, ERL 8228, Laboratoire Physiologie Rénale Tubulopathies, FrancePublished Online:30 Aug 2021https://doi.org/10.1152/ajprenal.00253.2021Mo...

This investigation, preliminary reports on parts of which have previously appeared (1, 2), presents data on the conversion in the intact rat of the labeled carbon of the following compounds to succinate: NaHC*03, CH&*OOH, C*H&*OOH, CH&HOHC*OOH, and C*H&*HOHCOOH. All the animals were injected with malonate to augment the urinary excretion of succinate (3). The latter was isolated from the urine ...

1. The influence of ethanol on the metabolism of livers from fed and starved rats has been studied in liver-perfusion experiments. Results have been obtained on oxygen consumption and carbon dioxide production, on glucose release and uptake by the liver and on changes in the concentrations of lactate and pyruvate and of beta-hydroxybutyrate and acetoacetate in the perfusion medium. 2. Oxygen co...

Survival and blood acid-base status were measured on freshwater turtles (Chrysemys picta bellii Gray) that were submerged at 3 °C in either aerated (high Oj) or N2-equilibrated (low O2) water. Results from catheterized turtles, without access to air under these conditions, and from noncatheterized turtles which were either apnoeic (in high O2 and low O2 water) or in high O2 water with access to...

Entry rates of glucose in sheep have been estimated by Annison & White (1961, 1962) by using isotope-dilution techniques. The values obtained were surprisingly large in view of the small absorption -of carbohydrate from the alimentary tract of sheep (Annison & Lewis, 1959) and the limited amount of .propionate available for conversion into glucose (Annison, Hill & Lewis,, 1957; Annison & Lindsa...

McFadden, Bruce A. (Washington State University, Pullman), and H. Robert Homann. Quantitative studies of the effect of organic substrates and 2,4-dinitrophenol on heterotrophic carbon dioxide fixation in Hydrogenomonas facilis. J. Bacteriol. 86:971-977. 1963.-Whole cells of Hydrogenomonas facilis under heterotrophic conditions fixed levels of C(14)O(2) which depended upon the nature of the carb...

Almost all enzyme kinetic studies have been based on measurement of net chemical reaction. Isotopic tracer techniques make possible other types of kinetic measurements, including the rate of interconversion of reactants or interchange of atoms between substrates at equilibrium.1 Only very limited studies have been reported of such equilibrium rate measurements with known concentrations of all r...

BACKGROUND The value of goal-directed fluid therapy in neurosurgical patients, where brain swelling is a major concern, is unknown. The aim of our study was to evaluate the effect of an intraoperative goal-directed fluid restriction (GDFR) strategy on the postoperative outcome of high-risk patients undergoing brain surgery. METHODS High-risk patients undergoing brain surgery were randomly ass...

1. Glycolysis by the supernatant fraction of homogenates of liver from guinea pigs and rats at various stages of development (foetal, newborn and adult) has been examined in a suitably fortified medium by measurement of inorganic phosphate uptake and production of lactate and glycerol 1-phosphate. 2. Starting with glucose as substrate, two rate-determining steps in glycolysis occur at the stage...