Naphthoquinones are compounds present in several families of higher plants. Their molecular structures confer redox properties, and they are involved in multiple biological oxidative processes. In folk medicine, especially among Indian populations, plants containing naphthoquinones have been employed for the treatment of various diseases. The biological redox cycle of quinones can be initiated ...

1 Inflammation & Healing Research Cluster, School of Health and Sport Sciences, University of the Sunshine Coast, Maroochydore, Queensland, Australia, 2 Infectious Diseases & Immunology Division, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, 3 Dermatology Department, Henri Mondor Hospital, AP-HP, UPEC, Créteil, France, 4 Université Paris-est Créteil Val de Marne, Cr...

Injectable Hydrogels In article number 2206554, Lin Yu and co-workers develop an injectable thermosensitive hydrogel with inherent long-acting NO-releasing capacity. The system loaded β-lapachone CuCys nanoparticles can synchronously boost intracellular reactive oxygen species nitrogen levels, thereby synergistically enhancing the anti-tumor efficacy. This is suitable as a platform for extendin...

Bone Regeneration In article number 2200298 by Wenguo Cui, Guochun Zha, Dechun Geng, and co-workers, a kind of lithium-based bioglasshydrogel is implanted in femoral defect diabetic rats. Photo-crosslinked hydrogel triggered blue light releases Si4+, Li+ other ions to promote osteogenesis, angiogenesis anti-inflammation. This work represents the delightful approach orchestrating bone regenerati...

Intestinal epithelial stem cells (IESCs) control the intestinal homeostatic response to inflammation and regeneration. The underlying mechanisms are unclear. Cytokine-STAT5 signaling regulates intestinal epithelial homeostasis and responses to injury. We link STAT5 signaling to IESC replenishment upon injury by depletion or activation of Stat5 transcription factor. We found that depletion of St...

INTRODUCTION Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possible that some inflammatory factors might contribute to liver damage at an earl...

1 Department of Mathematics, Utrecht University, Utrecht, Kingdom of the Netherlands. 2 Department of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, Kingdom of the Netherlands. 3 Eijkman Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, Utrecht, Kingdom of the Netherlands. 4 Julius Center for Health Rese...