BACKGROUND The transcription factor pituitary-1 (Pit-1) is mainly expressed in the pituitary gland, where it has critical roles in cell differentiation and as a transcriptional factor for GH and prolactin (PRL). It is also expressed in human extrapituitary tissues (placenta, lymphoid and haematopoietic tissues) and cell lines (human breast adenocarcinoma cells, MCF-7). Despite the widely sugges...

Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of intravenously injected antibodies for targeting tumors with the toxicity induced by photosensitizers after exposure to near infrared (NIR) light. Herein, we evaluate the efficacy of NIR-PIT in a mouse model of disseminated peritoneal ovarian cancer. In vitro and in vivo experiments were conduct...

Introduction: The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) is expressed in the mammary gland and its overexpression induces profound phenotypic changes in proteins involved in cell proliferation, apoptosis, and invasion. Patients with breast cancer and elevated expression of Pit-1 show a positive correlation with the occurrence of distant metastasis. In this stu...

this study was carried out on olive trees cv. amygdalifolia, to investigate the effect of spraying potassium nitrate, kno3, and zinc sulfate, znso4, on the fruit weight, dimension and volume. the plants were sprayed with 0, 0.5, 1.0 and 1.5% kno3 and 0, 0.25, 0.50 and 0.75% znso4 and their combinations in august about halfway through the fruit growth period. the highest fruit weight was observe...

In open-pit mine planning, the design of the most profitable ultimate pit limit is a prerequisite to developing a feasible mining sequence. Currently, the design of an ultimate pit is achieved through a computer program in most mining companies. The extraction of minerals in open mining methods needs a lot of capital investment, which may take several decades. Before the extraction, the p...

Planning and design procedure of an open pit mining project just can be started after ultimate pit determination. In the carried out study in this paper it was shown that the most important factor in ultimate pit determination and in consequence in the whole planning and design procedure of an open pit mine is the metal price. Metal price fluctuations in recent years were exaggerated and impose...

Residential biomass combustion has been pointed out as one of the largest sources atmospheric pollutants. Rising awareness environmental effects residential emissions boosted development different emission reduction devices that are currently available on market for small-scale appliances. However, detailed studies efficiency these in systems Southern European countries lacking. In this study, ...

Almost all post-exploitation open pit mines in the world are shaped as a final water reservoir. One of main hazards is slope stability lake banks. To develop reliability methodology for assessing long-term flooded open-pit lake, back analysis was conducted using 2D and 3D large-scale numerical models Lake Most, which one largest mining lakes Europe (Czech Republic). The model built, based on si...

OBJECTIVE Radioimmunotherapy (RIT) has proven effective for patients with relapsed and refractory lymphoma. However, new types of therapy are strongly desired as B-cell lymphoma remains incurable for many patients. Photoimmunotherapy (PIT) is an emerging targeted cancer therapy that uses photosensitizer (IR700)-conjugated monoclonal antibodies (mAbs) to specifically kill cancer cells. To evalua...