Toxoplasma gondii, a parasitic protozoan, infects about 30-60% of people worldwide. The latent toxoplasmosis, i.e. life-long presence of cysts in the brain and muscular tissues, has no effect on human health. However, infected subjects score worse in psychomotor performance tests and have different personality profiles than Toxoplasma-negative subjects. The mechanism of this effect is unknown; ...

Puroose Recurrent ocular toxoplasmosis is a major cause of blindness throughout the world. However, the pathogenetic mechanisms of reactivation of latent Toxoplasma gondii (T. gondii) infections are still unknqwn. An important question is whether the recurrent focal inflammatory responses in the retina are primarily directed against the parasite itself or whether autoimmune mechanisms play a ro...

Toxoplasmosis has historically been considered one of the most important opportunistic infections detected in HIV/AIDS patients. The prevalence rates of latent Toxoplasma infections in HIV-infected patients has been found to vary greatly from 3% to 97%. Prevalence has been found to be related to ethnicity, certain risk factors, and reactivation of toxoplasmosis. Prior to antiretroviral therapy,...

Puroose Recurrent ocular toxoplasmosis is a major cause of blindness throughout the world. However, the pathogenetic mechanisms of reactivation of latent Toxoplasma gondii (T. gondii) infections are still unknqwn. An important question is whether the recurrent focal inflammatory responses in the retina are primarily directed against the parasite itself or whether autoimmune mechanisms play a ro...

Bradyzoite-to-tachyzoite conversion plays a role in the pathogenesis of recrudescence of ocular toxoplasmosis and disease in immunocompromised persons. The currently available medicines are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. A previous study showed that the histone deacetylase inhibitor FR235222 has a dramatic effect on tachyzoite growth and induces t...

Puroose Recurrent ocular toxoplasmosis is a major cause of blindness throughout the world. However, the pathogenetic mechanisms of reactivation of latent Toxoplasma gondii (T. gondii) infections are still unknqwn. An important question is whether the recurrent focal inflammatory responses in the retina are primarily directed against the parasite itself or whether autoimmune mechanisms play a ro...

Background: Toxoplasma gondii is an intracellular protozoan with worldwide distribution capable of infecting all endothermic vertebrates. Latent toxoplasmosis in man and animals is considered as clinically asymptomatic. The aim of this Study is evaluation of the effects of Toxoplasma gondii on Biochemical Parameters of Reproductive Function in Male Rats. Materials and Methods: A total of 56 mal...

background: psychiatric patients have an increased risk of some infections like toxoplasmosis. investigations on toxoplasma gondii infection among psychiatric patients have been limited in mashhad, northeast of iran. in this case-control study, prevalence of t. gondii was investigated by serological method. methods: this case-control study was performed among psychiatric patients admitted to av...

Almost 30% of humans present a Toxoplasma gondii positive antibody status and its prevalence increases with age. The central nervous system is the main target. However, little is known about the influence of asymptomatic i.e. latent Toxoplasmosis on cognitive functions in humans. To investigate neurocognitive dysfunctions in asymptomatic older adults with T. gondii positive antibody status a do...