BACKGROUND Human lateralized behaviors relate to the asymmetric development of the brain. Research of the prenatal origins of laterality is equivocal with some studies suggesting that fetuses exhibit lateralized behavior and other not finding such laterality. Given that by around 22weeks of gestation the left cerebral hemisphere compared to the right is significantly larger in both male and fem...

Flatfishes, such as flounder, are the world's most asymmetric vertebrates. It is unknown if the development of lateralized swimming behavior during metamorphosis is an adaptive response to bilaterally asymmetric eye positioning, or if this results from a vestibular response to thyroid hormone. This study describes larval development in left-sided, right-sided and bilaterally symmetric variants ...

It has been hypothesized that cerebral lateralization can significantly enhance cognition and that this was one of the primary selective forces shaping its wide-spread evolution amongst vertebrate taxa. Here, we tested this hypothesis by examining the link between cerebral lateralization and numerical discrimination. Guppies, Poecilia reticulata, were sorted into left, right and non-lateralized...

Brain processes underlying spoken language comprehension comprise auditory encoding, prosodic analysis and linguistic evaluation. Auditory encoding usually activates both hemispheres while language-specific stages are lateralized: analysis of prosodic cues are right-lateralized while linguistic evaluation is left-lateralized. Here, we investigated to what extent the absence of prosodic informat...

PURPOSE Measurement of local cerebral blood flow (LCBF) is routinely used to locate the areas involved in generation and spread of seizures in epilepsy patients. Because the spatial distribution and extent of ictal CBF depends on the epileptogenic network, but also on the timing of injection of tracer, we used a rat model of amygdala-kindled seizures to follow the time-dependent changes in the ...

Patients with mesial temporal lobe epilepsy (MTLE) have cognitive dysfunctions not fully explained by the temporal seizure focus. Abnormal functional connectivity in the resting-state default mode network (DMN) appear to be related to these cognitive impairments. Studies showed DMN abnormalities in MTLE, but most combined patients with hippocampal sclerosis (HS) with other underlying etiologies...

background: serum prolactin level has been used as an alternative determinant to help differentiate epileptic from non-epileptic seizures. we aimed to analyze the association between serum prolactin concentration and epileptic seizure versus febrile seizure as well as seizure duration, single versus multiple seizure attacks and time lapse between seizure onset and blood sampling.   methods: sev...

PURPOSE To investigate the clinical significance of bilateral temporal hypometabolism (BTH) for patients with mesial temporal lobe epilepsy (MTLE) by using statistical parametric mapping (SPM). METHODS Interictal 18F-FDG PET scans were performed for 29 patients with surgically treated MTLE. Clinical data, interictal epileptiform discharges (IEDs), ictal scalp EEG and intracarotid amobarbital ...

BACKGROUND AND PURPOSE Noninvasive imaging plays a pivotal role in lateralization of the seizure focus in presurgical patients with temporal lobe epilepsy (TLE). Our goal was to evaluate the utility of diffusion tensor imaging (DTI) tractography in TLE. MATERIALS AND METHODS Twenty-one patients with TLE (11 right, 10 left TLE) and 21 controls were enrolled. A 1.5T MR imaging scanner was used ...