Eleven bisbenzylisoquinoline (BBIQ) alkaloids were studied for in vitro trypanocidal activity against trypomastigote forms of the Y strain of Trypanosoma cruzi. The inhibitory activity of these compounds against trypanothione reductase (TR), a target enzyme for chemotherapy against Chagas disease, was also studied. Six BBIQ alkaloids (antioquine, cepharanthine, daphnoline, limacine, cycleanine ...

Effect concentrations in fish LC50 tests with directly acting electrophiles are lower than those of unreactive chemicals that act by narcosis. LC50 values of more hydrophobic reactive chemicals tend to approach those of unreactive chemicals. Quantitative studies to correlate fish LC50 data to physical-chemical properties indicate that LC50 values of reactive chemicals depend on hydrophobicity a...

Artemia franciscana nauplii is a source of nutrients and pathogen vectors due to the non-selective nature filter feeder. Prevention pathogens done by adding iodine disinfectant suppress emergence bacteria. One way find out if substance toxic testing toxicity lethal concentration (LC50) on A. nauplii. The aim this study was evaluate effect determine in 50% (LC50). Brine Shrimp Lethality Test (BS...

In acute toxicity (96 hr) experiment the fingerlings of freshwater fish Labeo rohita was exposed to tannery, electroplating and textile mill effluents. The LC0 and LC50 concentrations were 15% and 20% for tannery effluents, 3% and 6% for electroplating effluents and 18% and 22% for textile mill effluents respectively. It was found that, electroplating effluent was more toxic than tannery and te...

As part of our continuing research on isoquinoline acaricidal drugs, this paper reports the preparation of a series of the 2-aryl-1-cyano-1,2,3,4-tetrahydroisoquinolines with various substituents on the N-phenyl ring, their in vitro acaricidal activities against Psoroptes cuniculi, a mange mite, and discusses their SAR as well. The structures of all compounds, including 12 new ones, were elucid...

The aim of this research was to determine the chemical composition of the essential oil of Acorus calamus rhizomes, its insecticidal activity against the booklouse, (Liposcelis bostrychophila) and to isolate any insecticidal constituents from the essential oil. The essential oil of A. calamus rhizomes was obtained by hydrodistillation and analyzed by GC-FID and GC-MS. A total of 32 components o...

The erythrocyte abnormality test was analyzed in kidney cells of freshwater fish, Labeo rohita exposed to tannery industry effluent. The 96h LC50 value of tannery effluent against fish was calculated by Finney method and it comes out to be 7.07%. Three sublethal concentrations on basis of 96h LC50 value (3.53%, 1.76% and 0.88%) were selected. Fishes were exposed to these concentrations for 24h,...

AIM The aim of this study was to isolate the bioactive compounds from the roots of Combretum adenogonium and assess for its antibacterial and cytotoxic properties. MATERIALS AND METHODS The extract was obtained using 20% aqueous ethanol and further subjected to fractionation with 1:1 n-butanol/water. Chromatographic analyses of the n-butanol fraction led to the isolation of compounds (1-3). T...

The larvicidal activities to determine the efficacies of acetone, ethyl acetate, chloroform and butanol dried leaf extracts of Annona squamosa, Cynodon dactylon, Melia azedarach and root extract of Hemidesmus indicus tested against 3 instar Culex quinquefasciatus and Aedes aegypti. The highest larvae mortality was found in the acetone followed by ethyl acetate, chloroform and butanol extract of...