نتایج جستجو برای: lead compounds

تعداد نتایج: 555612  

Journal: :Environmental toxicology and chemistry 2002
Agneta Göthberg Maria Greger Bengt-Erik Bengtsson

The aquatic plant water spinach (Ipomoea aquatica), either wild or cultivated, is found throughout Southeast Asia and is a widely consumed vegetable in the region. Many of the waters where I. aquatica grows serve as recipients for domestic and other types of wastewater. Because these waters contain not only nutrients, but often also a wide variety of pollutants such as heavy metals from various...

2015
Peter H. Santschi Chin-Chang Hung Degui Tang Susan Gonzalez

1) Concentration determination and isolation of purified fractions of natural thiols and natural acid polysaccharides for trace metal complexation and structural experiments. 2) Determination of conditional stability constants for the complexation of selected B metal ions (such as Ag, Hg, Cd, Cu, Pb) to specific thiolic functional groups in estuarine organic matter, and of A (e.g., Cs, Ba, Th) ...

2017
Justin M Lopchuk Kasper Fjelbye Yu Kawamata Lara R Malins Chung-Mao Pan Ryan Gianatassio Jie Wang Liher Prieto James Bradow Thomas A Brandt Michael R Collins Jeff Elleraas Jason Ewanicki William Farrell Olugbeminiyi O Fadeyi Gary M Gallego James J Mousseau Robert Oliver Neal W Sach Jason K Smith Jillian E Spangler Huichin Zhu Jinjiang Zhu Phil S Baran

Driven by the ever-increasing pace of drug discovery and the need to push the boundaries of unexplored chemical space, medicinal chemists are routinely turning to unusual strained bioisosteres such as bicyclo[1.1.1]pentane, azetidine, and cyclobutane to modify their lead compounds. Too often, however, the difficulty of installing these fragments surpasses the challenges posed even by the constr...

Journal: :Annals of agricultural and environmental medicine : AAEM 2013
Sławomir Kasperczyk Iwona Błaszczyk Michał Dobrakowski Ewa Romuk Lucyna Kapka-Skrzypczak Mariusz Adamek Ewa Birkner

The most important biothiols include glutathione, homocysteine (HCY), cysteine and proteins. The aim of the presented study was to evaluate the influence of lead on the biothiol turnover--the concentration of HCY and protein sulfhydryl groups (P-SH) in the serum and reduced glutathione (G-SH) in erythrocytes--in individuals (employees of metal works) exposed to lead and to evaluate its probable...

Journal: :Current opinion in chemical biology 2012
Gilles Gasser Nils Metzler-Nolte

Organometallic complexes have unique physico-chemical properties, which have been widely used in homogenous catalysis, for example, for the synthesis of lead compounds and drug candidates. Over the past two decades, a few scientists from all over the world have extended the use of the specific characteristics of these compounds (e.g. structural diversity, possibility of ligand exchange, redox a...

2016
Tomoya Hakamata Kohei Shimamura Fuyuki Shimojo Rajiv K. Kalia Aiichiro Nakano Priya Vashishta

Organometal halide perovskites are attracting great attention as promising material for solar cells because of their high power conversion efficiency. The high performance has been attributed to the existence of free charge carriers and their large diffusion lengths, but the nature of carrier transport at the atomistic level remains elusive. Here, nonadiabatic quantum molecular dynamics simulat...

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