Insulin resistance is the principle step towards the progression of type 2 diabetes, and has been linked to increased circulating levels of cytokines, leading to chronic low-grade inflammation. Specifically, in chronic disease states increased IL-6 is thought to play a critical role in the regulation of insulin resistance in the peripheral tissues, and has been used as a marker of insulin resis...

animal studies have reported very useful properties including weight loss and improved body composition for conjugated linoleic acid (cla). however, there is limited information about the combined effect of resistance training and cla supplementation. therefore, the effect of cla supplementation and resistance training on body composition, serum leptin and muscle strength in non-athlete men was...

Cancer drug resistance continues to be a major impediment in medical oncology. Clinically, resistance can arise prior to or as a result of cancer therapy. In this review, we discuss different mechanisms adapted by cancerous cells to resist treatment, including alteration in drug transport and metabolism, mutation and amplification of drug targets, as well as genetic rewiring which can lead to i...

automobile body plays crucial role in preventing the collision energy transfer in severe accidents to the passengers. if the collision energy is dissipated or saved in bumper or chassis, the amount of damage to the occupants would be minimized. using novel laminated panel (fiber metal laminate) in auto body, and considering the characteristics such as high energy absorption, strength, high dent...

Topoisomerases are a family of vital enzymes capable of resolving topological problems in DNA during various genetic processes. Topoisomerase poisons, blocking reunion of cleaved DNA strands and stabilizing enzyme-mediated DNA cleavage complex, are clinically important antineoplastic and anti-microbial agents. However, the rapid rise of drug resistance that impedes the therapeutic efficacy of t...