Left ventricular hypertrophy due to aortic stenosis, hypertension and other forms of heart disease is associated with abnormalities of diastolic function. It is uncertain whether these changes are an inherent consequence of the hypertrophic process or represent additional pathologic factors. To investigate this issue, echocardiographic indexes of left ventricular early diastolic function in hig...

Hypertrophic cardiomyopathy is a disease of cardiac muscle that is often genetically transmitted as. an autosomal dominant trait and is characterized by a wide variety of patterns of left ventricular hypertrophy that may be identified with wide-angle, two-dimensional echocardiography. To determine the degree to which left ventricular morphology is similar in related patients with hypertrophic c...

In less than a decade since development of echocardiographic measurement of left ventricular muscle mass, studies using this technique have provided considerable information about the prevalence and pathophysiology of left ventricular hypertrophy in human hypertension. Increased left ventricular mass has been found in a significant minority of patients with systemic hypertension, with the exact...

BACKGROUND Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone. In chronic kidney disease (CKD), circulating FGF-23 levels are markedly elevated and independently associated with mortality. Left ventricular hypertrophy and coronary artery calcification are potent risk factors for mortality in CKD, and FGFs have been implicated in the pathogenesis of both myocardial hypertrop...

OBJECTIVES: In athletes, isolated electrocardiogram high voltage criteria are widely used to evaluate left ventricular hypertrophy, but positive findings are thought to represent normal electrocardiogram alterations. However, which electrocardiogram criterion can best detect left ventricular hypertrophy in athletes of various sport modalities remains unknown. METHODS: Five electrocardiogram c...

Objective: To evaluate the relation between QT variables and disproportion of left ventricular wall hypertrophy in patients with hypertrophic cardiomyopathy. Design: Retrospective analysis of the results of echocardiography and electrocardiography. Setting: University hospital (tertiary referral centre). Patients: 70 patients with hypertrophic cardiomyopathy were divided into four groups accord...

OBJECTIVES We sought to compare the predictive value of echocardiographically determined left ventricular hypertrophy on death from all causes and cardiac mortality using various methods of indexation for left ventricular mass. BACKGROUND Considerable controversy exists regarding the optimal method for indexing left ventricular mass to body size in the clinical setting. METHODS The study in...

Left ventricular remodelling after infarction Many factors influence the survival of patients after myocardial infarction, but the single most important clinical determinant is left ventricular function.1-3 Left ventricular function correlates closely with the size of the region of myocyte necrosis in human and in animal infarction models.45 Recently, the cellular processes occurring soon after...

OBJECTIVE To evaluate the relation between QT variables and disproportion of left ventricular wall hypertrophy in patients with hypertrophic cardiomyopathy. DESIGN Retrospective analysis of the results of echocardiography and electrocardiography. SETTING University hospital (tertiary referral centre). PATIENTS 70 patients with hypertrophic cardiomyopathy were divided into four groups acco...

Reduction in the Risk of Cardiovascular Morbidity and Mortality in Hypertensive Patients with Left Ventricular Hypertrophy HYZAAR is a combination of losartan (COZAAR) and hydrochlorothiazide. In patients with hypertension and left ventricular hypertrophy, losartan, often in combination with hydrochlorothiazide, reduces the risk of cardiovascular morbidity and mortality as measured by the combi...