To determine the time course of changes in left ventricular diastolic properties after a large myocardial infarction, we serially measured left ventricular relaxation, chamber stiffness, and the ratio of left ventricular cavity to wall volume (V/VW) after coronary artery ligation in rats. Left ventricular relaxation was measured during the occlusion and then both relaxation and chamber stiffnes...

BACKGROUND Previous studies have reported an important role for right ventricular function in the pathophysiology of the low cardiac output state that can accompany right ventricular infarction. Some studies have suggested that right ventricular distensibility impairs right ventricular filling and stroke output; others have demonstrated that the pericardium can mediate depressed left ventricula...

background: the prevalence of patients with severe left ventricular dysfunction (lvd) referred for coronary artery bypass grafting (cabg) is increasing. preoperative lvd is an established risk factor for early and late mortality after revascularization. the aim of the present study was to assess the early outcome of patients with severe lvd undergoing cabg. methods: between december 2012 and no...

introduction: left ventricular ejection fraction (lvef) is considered to be the single most important prognostic factor in patients with previous myocardial infarction. lvef is not improved in all patients after coronary artery bypass grafting (cabg). this study aimed to assess the possibility of prediction of lvef changes after cabg using myocardial perfusion gated signle photon emission compu...

hypertonic saline solution can absorb part of the intracellular fluid volume into the extracellular space. the effects of this solution on the cardiovascular system are increased coronary flow and increased left ventricular contraction, without sympathetic system activation. this study was designed to assess the effects of hypertonic saline solution in open heart surgery and to compare it with ...

OBJECTIVE Rapid ventricular pacing produces a reliable model of heart failure. Cessation after 4 weeks of rapid ventricular pacing results in rapid normalization of left ventricular function, but the left ventricle remains persistently dilated. We present novel data that show that prolonged rapid ventricular pacing (10 weeks) creates a model of chronic left ventricular dysfunction. METHODS In...

We studied the effects of right ventricular ischemia on left ventricular three-dimensional geometry and the end-diastolic pressure-volume relationship in 16 open-chest dogs before and after pericardiectomy. Left ventricular volume was calculated from three internal dimensions measured with ultrasonic crystals. In one group of eight dogs, right coronary artery (RCA) occlusion for 2 min with the ...

Thirty-one left ventricular (LV) biplane angiograms were performed in 28 patients with tricuspid atresia. Measurements of left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume were obtained by the modified Simpson's rule and systolic ejection fraction (EF) calculated. Left ventricular volumes and ejection fractions were also obtained in 19 control patients with ...

To test the hypothesis that the effects of positive end-expiratory airway pressure (PEEP) on intracavitary left ventricular end-diastolic pressure (LVEDP) depend on the ventricular filling conditions under which PEEP is applied, the effects of PEEP on pressure in and around the left ventricle were determined before and after stepwise expansion of intravascular blood volume in 10 closed-chest do...

The dynamics of acute mitral regurgitation were studied in six open-chest dogs in whom a portion of the anterior leaflet was excised. Phasic mitral and aortic flows were measured electromagnetically and left ventricular filling volume, regurgitant volume (RV) and forward stroke volume (SV) were calculated. The systolic pressure gradient (SPG) between the left ventricle (LV) and left atrium (LA)...