background: considering the prevalence of leishmaniasis in iran and many side effects associated with pentavalent antimony compounds use in its treatment, this study was designed to evaluate the effect of artemisia sieberi essence on the experimental ulcers of cutaneous leishmaniasis on balb/c mice. methods: this experimental research was performed to determine the effect of various concentrati...

objective(s) annual incidence of cutaneous leishmaniasis is increasingly growing and development of the alternative drugs against it is a major concern. artemisia genus is a traditional medicinal plant in iran. the aim of this study was to examine the leishmanicidal activity of various iranian artemisia species extracts. materials and methods different extracts were gathered from eleven iranian...

background: in leishmaniasis, some drugs prescribed for treatment have toxic ef-fects and there are reports about drug resistance in some countries. due to this fact, using herbal drugs such as artemisinin with good efficacy and low toxic effect might be suitable. methods: we evaluated the apoptotic effect of artemisinin on leishmania major in vitro and the antileishmanial activities of artemis...

background: the objectives of our research were to search for leishmania species in rodents in fars province, south of iran, and to compare molecular with conventional methods for detecting these para-sites. methods: rodents were captured using live traps and screened for leishmania species using molecular and conventional methods, including the taking of smears from each ear. nested pcr was em...

leishmaniasis is caused by parasitic protozoa of the genus leishmania. cutaneous leishmaniasis (cl) is a complex disease with wide spectrum of clinical manifestations. in order to identify leishmania species causing cl in isfahan by a definite molecular technique (pcr method), this study was undertaken over 2010- 2011. 124 patients with suspicious lesion of leishmaniasis and positive direct sme...

INTRODUCTION Serological screening in blood banks does not include all transmittable diseases. American cutaneous leishmaniasis (ACL) has a high detection rate in the municipalities of the State of Paraná. METHODS This study analyzed the presence of anti- Leishmania braziliensisantibodies in 176 blood donors who live in these endemic areas. The variables were analyzed with the χ2 test and Sta...

Upon their recruitment to a site of infection and their subsequent activation, neutrophils release DNA and a subset of their granule content to form filamentous structures, known as neutrophil extracellular traps, which capture and kill microorganisms. In this study, we show that Leishmania promastigotes induced the rapid release of neutrophil extracellular traps from human neutrophils and were...

During 2013-2015, prevalence of cutaneous leishmaniasis in war-affected Waziristan areas was 3.61% by PCR. Youths (1-15 years of age) were more susceptible. Internal transcribed spacer 1 PCR followed by restriction fragment length polymorphism analysis identified Leishmania tropica in 215 samples and Leishmania major in 6 samples.