Avian paramyxoviruses (APMV) are divided into nine serotypes. Newcastle disease virus (APMV-1) is the most extensively characterized, while relatively little information is available for the other APMV serotypes. In the present study, we examined the pathogenicity of two divergent strains of APMV-3, Netherlands and Wisconsin, in (i) 9-day-old embryonated chicken eggs, (ii) 1-day-old specific pa...

Newcastle disease virus (NDV) is an economically important poultry pathogen with a worldwide distribution that may infect a wide range of domestic and wild avian species. The identification of different pathotypes of NDVs plays an important role in the diagnosis and development of vaccines to control and eradicate NDV infections. In our previous study, we showed that mono-specific antibodies ca...

Despite routine vaccination programs against Newcastle disease (ND), sporadic cases have occasionally occurred that remain a constant threat to commercial poultry. Ten isolates of Newcastle disease viruses (NDV) from infected broiler chicken cases were obtained from various locations in Fars province during 2009-2011 and genetically analyzed using reverse transcription polymerase chain reaction...

Current vaccination strategies for commercial poultry using live attenuated and inactivated Newcastle disease (ND) vaccines have some limitation and difficulties, and new vaccines with distinct features are needed. Recently, in ovo vaccination technology is concerned as a safe, efficacious, and convenient method. Common ND vaccines used in chickens cannot be employed in ovo due to embryo toxici...

The control of Newcastle disease (ND) in South Africa has proved difficult since 2002 following the introduction of lineage 5d/VIId Newcastle disease virus (NDV) strain ("goose paramyxovirus" - GPMV) to which commercially available ND vaccines appeared less effective. Most of the ND infections, even in fully vaccinated hens were characterized consistently by a drop in egg production. In this st...

•Oncolytic viruses have shown significant promise in glioma management.•Food and Drug Administration (FDA) approval for oncolytic virus melanoma has accelerated expansion of the field.•FDA granted Fast Tract Designation PVSRIPO DNX2401 tumors.•A compendium completed human trials summarizes development field.•Combining therapy with other immunotherapeutics is future field. Gliomas remain one mor...