objective: to compare the effectiveness of letrozole and clomiphene citrate (cc) on uterine blood flow rate in patients with unexplained infertility. materials and methods: in this randomized clinical trial 90 women with unexplained infertility referred to a university clinic from january 2011- december 2013 were enrolled. thirty patients were randomized for letrozole, 30 patients for cc and 3o...

The use of third-generation aromatase inhibitors (AIs), such as anastrozole and letrozole, as initial adjuvant hormonal therapy in postmenopausal women (PMW) with hormone receptor-positive (HR+) breast cancer offers a significant benefit over tamoxifen for reducing recurrence risk. Clinical studies, including the Arimidex Tamoxifen Alone or in Combination (ATAC) and the Breast International Gro...

The aim of this study was to systematically compare the clinical efficacy and safety of letrozole with clomiphene citrate for ovulation induction in women with polycystic ovary syndrome (PCOS). The Cochrane Central Register of Controlled Trials, PubMed, EMbase, CBMdisc and CNKI were searched for eligible randomized controlled trials (RCT) comparing letrozole with clomiphene citrate in PCOS pati...

Inhibitors of aromatase, the final enzyme of estradiol synthesis, are suspected of inducing memory deficits in women. In previous experiments, we found hippocampal spine synapse loss in female mice that had been treated with letrozole, a potent aromatase inhibitor. In this study, we therefore focused on the effects of letrozole on long-term potentiation (LTP), which is an electrophysiological p...

Background Joint symptoms are a common side effect of aromatase inhibitors. However, it is not known if the risk of these symptoms varies between the members of this drug class. The aim of this study was to compare the frequency of joint symptoms associated with anastrozole and that associated with letrozole. Methods We retrospectively reviewed patients with breast cancer who were treated wit...

INTRODUCTION Eruptive keloids are rarely described in the literature and are typically reported in association with a systemic disease. Because reports of eruptive keloids are sparse, the pathophysiology of eruptive keloids remains to be clearly explained. We report a case of a 77-year-old woman who had extensive eruptive keloids while taking letrozole for hormone receptorepositive infiltrating...

Clomiphene citrate has been traditionally used as the drug of choice in treating women with anovulatory infertility. In the last decade letrozole, an aromatase inhibitor has emerged as alternative ovulation induction agent. Literature confirms that letrozole has a definitive role in anovulatory women who have not responded to the clomiphene therapy. However its role as an alternative to clomiph...

Abstract The occurrence of three anticancer drugs (gemcitabine, letrozole, tamoxifen) was studied in wastewater samples from two local treatment plants (WWTPs) Finland. Studied pharmaceuticals were selected, as are potential to cause adverse effects on organisms even at low concentrations, but they seldom included the analysis emerging contaminants. concentration determined by liquid chromatogr...

The clinical development of aromatase inhibitors has been largely confined to postmenopausal breast cancer patients and strongly guided by pharmacological data. Comparative oestrogen suppression has been helpful in circumstances in which at least one of the comparitors has caused substantially non-maximal aromatase inhibition. However, the triazole inhibitors, letrozole and anastrozole, and the...