T cell activation is associated with a dramatic reorganization of cell surface proteins and associated signaling components into discrete subdomains within the immunological synapse in T cell:APC conjugates. However, the signals that direct the localization of these proteins and the functional significance of this organization have not been established. In this study, we have used wild-type and...

Recently, we have demonstrated that antibodies that block the function of the b2-integrin leukocyte function-associated antigen-1 (LFA-1) completely abrogate the rapid mobilization of hematopoietic progenitor cells (HPC) with colonyforming and radioprotective capacity induced by interleukin-8 (IL-8) in mice. These findings suggested a direct inhibitory effect of these antibodies on LFA-1–mediat...

Serological and biochemical studies using monoclonal antibodies have demonstrated that the Ly-15 cell membrane alloantigens are polymorphic sites on the lymphocyte function-associated antigen-1 (LFA-1) molecule. Ly-15.2 and LFA-1 show identical tissue distributions, being present on all thymocytes, lymphocytes, and neutrophils, and flow cytofluorometric analysis indicated identical cell surface...

Three sensitive and specific assays, the lateral flow assay (LFA), polymerase chain reaction assay (PCR) and reversed passive latex agglutination assay (RPLA), were selected for detection of staphylococcal enterotoxin B (SEB) from 77 clinical Staphylococcus aureus strains isolated from humans. Analytical results revealed that the LFA has almost the same detection sensitivity as that of PCR and ...

Background The prevalence of foot osteoarthritis (OA) is much less understood than hip, knee and hand OA. The foot is anatomically complex and different researchers have investigated different joints with lack of methodological standardisation across studies. The La Trobe Foot Atlas (LFA) is the first to address these issues in providing quantitative assessment of radiographic foot OA, but has ...

BACKGROUND Activation of the immune system in terms of subseptic conditions during liver regeneration is of paramount clinical importance. However, little is known about molecular mechanisms and their mediators that control hepatocyte proliferation. We sought to determine the functional role of immune cells, especially NKT cells, in response to partial hepatectomy (PH), and to uncover the impac...

With the evolution of the Internet, a huge number of realtime applications, like Voice over IP, has started to use IP as primary transmission medium. These services require high availability, which is not amongst the main features of today’s heterogeneous Internet where failures occur frequently. Unfortunately, the primary fast resilience scheme implemented in IP routers, Loop-Free Alternates (...

The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and αLβ₂), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We con...

Distributed link-state routing protocols, including Open Shortest Path First (OSPF) and Intermediate System–Intermediate System (IS-IS), have successfully provided robust shortest path for IP networks. However, is inflexible sometimes results in congestion on some critical links. By separating the control plane data plane, centralized of Software Defined Networking (SDN)-based approach possesse...

The adhesion molecules LFA-1 and ICAM-1 are considered to be critically involved in cell fusion and multinucleated giant cell (MGC) formation (1). Alveolar macrophages of patients with pulmonary sarcoidosis show increased expression of LFA-1 and ICAM1 (2) and, importantly, it has been shown that MGC formation can be blocked by anti-LFA-1 and anti-ICAM-1 antibodies (1). LFA-1/ICAM-1 interaction ...