Insulin-like growth factor I (IGF-I) is essential for normal intrauterine and postnatal growth and development. Using the Cre/loxP-induced conditional knockout system, we have established a liver-specific IGF-I-deficient (LID) mouse model. Circulating IGF-I levels were decreased by approximately 75% without any apparent effect on their growth and development. To determine the role of extra-hepa...

We propose a novel universal acoustic characterization approach to spoken language identification (LID), in which any spoken language is described with a common set of fundamental units defined “universally.” Specifically, manner and place of articulation form this unit inventory and are used to build a set of universal attribute models with data-driven techniques. Using the vector space modeli...

OBJECTIVE Progressive myopia in humans and lid-sutured myopia in primates have been considered to be different processes. This report seeks to establish the connection between progressive myopia in humans and lid suture myopia in macaque monkeys. METHODS We followed the axial length of 4 lid-sutured macaque monkeys over an 18 month period. Their axial length is directly related to myopia. We ...

Levodopa-induced dyskinesia (LID) is a major complication of long-term dopamine replacement therapy for Parkinson's disease, and becomes increasingly problematic in the advanced stage of the disease. Although the cause of LID still remains unclear, there is accumulating evidence from animal experiments that it results from maladaptive plasticity, resulting in supersensitive excitatory transmiss...

L-dopa-induced dyskinesia (LID) is a common debilitating complication of dopamine replacement therapy in Parkinson's disease. Recent evidence suggests that LID may be linked causally to a hyperactivation of the Ras-ERK signaling cascade in the basal ganglia. We set out to determine whether specific targeting of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1), a brain-specific activator of ...

— This paper presents a brief survey of feature extraction techniques used in language identification (LID) system. The objective of the language identification system is to automatically identify the specific language from a spoken utterance. Also the LID system must perform quickly and accurately. To fulfill this criteria the extraction of the features of acoustic signals is an important task...

A 10-year-old male, Muslim child diagnosed with xeroderma pigmentosa with a right upper lid malignancy presented as a therapeutic challenge because of the non-availability of normal facial skin for grafting and lid reconstruction. The lid lesion had been present for the last one month. The disease had been present for past five years with polymorphous, erythematous lesions all over the body. On...

Language Identification (LID) of speech can be split into two processes; phone recognition and language modelling. This two stage approach underlies some of the most successful LID systems. As phone recognizers become more accurate it is useful to simulate a very accurate phone recognizer to determine the effect on the overall LID accuracy. This can be done by using phone transcripts. In this p...

Group II chaperonins are ATP-dependent ring-shaped complexes that bind nonnative polypeptides and facilitate protein folding in archaea and eukaryotes. A built-in lid encapsulates substrate proteins within the central chaperonin chamber. Here, we describe the fate of the substrate during the nucleotide cycle of group II chaperonins. The chaperonin substrate-binding sites are exposed, and the li...

One-shot neural architecture search (NAS) substantially improves the efficiency by training one supernet to estimate performance of every possible child (i.e., subnet). However, inconsistency characteristics among subnets incurs serious interference in optimization, resulting poor ranking correlation subnets. Subsequent explorations decompose weights via a particular criterion, e.g., gradient m...