Motor impairment and functional limitations are known sequelae of Parkinson's disease. Occupational therapy (OT) is recognized as an important adjunct to pharmacological management. This critical review provides an update on the effectiveness of OT. Eight studies were included in the review, three on occupational therapy task-related training, two on functional training with external cues and t...

Recent progress in our understanding of the human immunodeficiency virus type 1 (HIV-1) life cycle has lead to the identification and characterization of viral genes or gene products that have been evaluated as targets for gene therapy. Virtually every stage in the viral life cycle and every viral gene product is a potential target. Gene therapy approaches directed at several of these viral tar...

UNLABELLED Spinal cord injury (SCI) and amyotrophic laterals sclerosis (ALS) are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives. OBJECTIVE The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and ...

OBJECTIVE: The objective of this selective EBM review is to determine whether or not music therapy is effective in improving the quality of life in dementia patients. STUDY DESIGN: Review of three English language primary studies published between 1996 and present. DATA SOURCES: Randomized, controlled clinical trials (RCTs) analyzing music therapy and dementia were found using PubMed and OVID. ...

Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy that has recently become highly instrumental in the fight against life-threatening diseases. A variety of modeling and computational simulation efforts have addressed different aspects CAR therapy, including activation, T- malignant cell population dynamics, therapeutic cost-effectiveness strategies, patient survival. In this ar...

Classical CBT has its limitation related especially to existential questions, such as meaning of life, acceptance of unchangeable aspects, meaning of values, transcendence, significance of experiences, and heading into the future. The method is a speculative review. It is a theoretical article, with discussion of concepts and possibilities for integration, rather than an analysis. The review in...

PURPOSE OF REVIEW To review studies of various physical therapy programs in ankylosing spondylitis and identify their benefits and potential indications in the treatment of this disease. RECENT FINDINGS Various exercise and physical therapy programs have been evaluated in clinical studies. Home exercise programs have been shown to improve symptoms, mobility, function and overall quality of li...