Dietary components responsible for the regulation of somatomedin-C in humans were assessed in five adult volunteers of normal weight who were fasted for 5 d on three occasions, then refed three diets of differing composition. The serum somatomedin-C decreased from a mean prefasting value of 1.85 +/- 0.39 U/ml (+/- 1 SD) to 0.67 +/- 0.16 U/ml at the end of fasting (P less than 0.005). After refe...

the insulin-like growth factor i receptor (igf-ir) plays an essential role in the establishment and maintenance of transformed phenotype. interference with the igf-ir pathway by antisense causes reversal of the transformed phenotype in many rodent and human tumor cell lines. we stably transfected the pc-3 human prostate cancer cell line with an igf-ir antisense rna expression plasmid. the numbe...

background: the transcription factor 7-like 2 gene (tcf7l2) is an element of the wnt signaling pathway. there is lack of evidence if tcf7l2 has a functional role in lipid metabolism and regulation of the components constitutes the metabolic syndrome (metsyn).the aims of this study were to evaluate whether the risk allele of tcf7l2 gene polymorphism is associated with dyslipidemia and metsyn. ma...

baluchi sheep is considered as the most common breed in iran, constituting about 30% of total sheep population, approximately 15 million heads. this research was designed to study the incidence of mutation in two loci of igf-i (exon 3) and adrb3 (intron) along with their association with body weight traits in baluchi sheep population. following dna extraction from 190 baluchi sheep, two pairs o...

The atmospheres of close-in extrasolar planets absorb most of the incident stellar radiation, advect this energy, then reradiate photons in preferential directions. Those photons carry away momentum, applying a force on the planet. Here we evaluate the resulting secular changes to the orbit, known as the Yarkovsky effect. For known transiting planets, typical fractional changes in semi-major ax...

PURPOSE There is a need to identify lung cancer prevention mechanisms. All-trans-retinoic acid (RA) was reported previously to inhibit N-nitrosamine-4-(methylnitrosamino)-1-(3 pyridyl)-1-butanone (NNK) carcinogenic transformation of BEAS-2B human bronchial epithelial cells (J. Langenfeld et al., Oncogene, 13: 1983-1990, 1996). This study was undertaken to identify pathways targeted during this ...

The enterovirus 2B protein contains a putative amphipathic alpha-helix that includes three positively charged and one negatively charged residue. Previously, we observed that replacement of the glutamic acid-40 residue with a lysine residue (mutation 2B-E[40]K) in the amphipathic alpha-helix of the coxsackie B3 virus 2B protein resulted in a quasi-infectious phenotype. On one occasion, however,...

Adenosine (ADO) signaling is altered in both asthma and chronic obstructive pulmonary disease, and the A(2B) adenosine receptor (A(2B)-R) may drive pulmonary inflammation. Accordingly, it has been proposed that specific inhibition of the A(2B)-R could treat inflammatory lung diseases. However, stimulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by ADO may be crucial in...