Two previously undescribed activators of prekallikrein have been purified from human plasma by alcohol frac tionation, ion exchange chromatography, gel filtration, and polyacrylamide gel electrophoresis. Both were apparently homogeneous as judged by electrophoretic mobility and molecular weight. A monomer-dimer relationship between these two activators is suggested by the use of disc gel electr...

Human neutrophils, activated by phorbol-myristate acetate (PMA). (A-neutrophils), were found to suppress lymphocytic killer (K) cell-mediated antibody-dependent cellular cytotoxicity (ADCC). Resting (R) neutrophils, ie, PMAuntreated cells, were completely ineffective. Suppression was optimal when A-neutrophils were added at the beginning of the ADCC assay. Furthermore, A-neutrophils were found ...

Renata B. de Oliveira, Ricardo J. Alves*, José Dias de Souza Filho and Maria Auxiliadora F. Prado Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-200 Belo Horizonte MG, Brazil Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Olegário Maciel 2360, 30180-112 Belo Hor...