BACKGROUND It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be valid if there is a large amount of plasma protein binding because the effective capillary permeability depends on the product of the intrinsic capillary permeability (PS) and the fraction of solute that is fre...

A functional relationship between two variables, applied mass to a weighing platform and estimated mass using Multi-Layer Perceptron Artificial Neural Networks is approximated by a linear function. Linear relationships and correlation rates are obtained which quantitatively verify that the Artificial Neural Network model is functioning satisfactorily. Estimated mass is achieved through recallin...

The high interest in the prediction of the intestinal absorption for New Chemical Entities (NCEs) is generated by the increasing rate in the synthesis of compounds by combinatorial chemistry and the extensive cost of the traditional evaluation methods. Quantitative Structure–Permeability Relationships (QSPerR) of the intestinal permeability across the Caco-2 cells monolayer (PCaco-2) could be o...

Small-scale probe permeability measurements on differently oriented faces of highly compacted and quartz-cemented Viking Formation sandstones yield detailed permeability distributions that appear to be diagnostic of the grainand lamina-scale fabric of the samples. Permeability anisotropy of a single ‘structureless'-appearing sample is low, reflected by a kV / kH-ratio of 0.7; corresponding k-di...

the objective of the present research is to study the effect of the social capital on the competitive behavior of the companies with the applied nature. the research method is descriptive-analytic and has a correlational type.the statistical population of the research includes sixty managers of the food industry companies in hamedan. the statistical sample of the research includes fifty two man...

in this paper, a finite element model is developed for the fully hydro-mechanical analysis of hydraulic fracturing in partially saturated porous media. the model is derived from the framework of generalized biot theory. the fracture propagation is governed by a cohesive fracture model. the flow within the fracture zone is modeled by the lubrication equation. the displacement of solid phase, and...

It is well known that the permeability and density of an aggregate decreases with its size, affecting its settling velocity and coagulation rate (rate of particle capture) with other particles. This change in aggregate density with size can be described by fractal scaling relationships. Two distinctly different fractal scaling approaches, however, have been used to describe aggregate permeabili...