Statistical models for genetic linkage analysis of k locus diseases are k-dimensional subvarieties of a (3 − 1)-dimensional probability simplex. We determine the algebraic invariants of these models with general characteristics for k = 1, in particular we recover, and generalize, the Hardy-Weinberg curve. For k = 2, the algebraic invariants are presented as determinants of 32 × 32-matrices of l...

Figure 1: Visualizations of correlation for a dataset containing 22,000 variables. The left two images show the correlation coefficients using a heatmap, clustered with (a) average linkage, and (b) complete linkage. The visible patterns in the heatmap are highly dependent on the clustering algorithm. In (c), our novel s-CorrPlot spatially encodes correlation coefficients, highlighting very diff...

The domesticated silkworm, Bombyx mori, is of high commercial importance as a silk producer and is also widely used for implementation of basic and applied research. It is important to understand its genome organization using molecular markers for genetic studies and for breeding purposes. In this study, a genetic linkage map using 204 amplified fragment length polymorphism (AFLP) markers was d...

To increase the likelihood of finding genetic variation conferring liability to eating disorders, we measured over 100 attributes thought to be related to liability to eating disorders on affected individuals from multiplex families and two cohorts: one recruited through a proband with anorexia nervosa (AN; AN cohort); the other recruited through a proband with bulimia nervosa (BN; BN cohort). ...

al2o3-sio2 diphasic gel was synthesized by sol gel route from aluminium nitrate and silicic acid following aqueous phase colloidal interaction. the precursor gel powder was thoroughly characterized by chemical analysis, measurement of surface area and bulk density measurement. the gel powder was further characterized by thermogravimetry, xrd diffraction study of the heat treated samples and sca...