A configuration of a linkage $$\Gamma $$ is possible positioning in $${{\mathbb {R}}}^{d}$$ , and the collection all such forms space $${\mathcal {C}}(\Gamma )$$ . We here introduce notion symmetric linkage, which we identify configurations are geometrically indistinguishable. show that planar polygon has regular cell structure, provide some principles for calculating this give complete descrip...

The ubiquitin proteasome system (UPS) directs programmed destruction of key cellular regulators via posttranslational modification of its targets with polyubiquitin chains. These commonly contain Lys-48 (K48)-directed ubiquitin linkages, but chains containing atypical Lys-11 (K11) linkages also target substrates to the proteasome--for example, to regulate cell cycle progression. The ubiquitin l...

The growing use of the CRIS-CERIF concept in combination with the natural development of research information systems de facto leads to a certain standardization of the systems, e.g. concerning content, a set and a structure of information objects that they are operating with. Modern research information systems operate with virtually the same set of objects: "person," "organization," "project,...

Introduction Tourism is considered as one of the fascinating facets of the socio-economic development of modern times. It is about people, places, structures and interactions of varying nature and intensities that eventually contribute emergence of a diverse set of outcomes viz. economic, socio-cultural and environmental. Perhaps the reach and linkages of tourism is far wider and complex and th...

We prove realizability theorems for vector-valued polynomial mappings, real-algebraic sets and compact smooth manifolds by moduli spaces of planar linkages. We also establish a relation between universality theorems for moduli spaces of mechanical linkages and projective arrangements.

Disulfide bonds stabilize the structure and functions of the hemagglutinin neuraminidase attachment glycoprotein (HN) of Newcastle disease virus. Until this study, the disulfide linkages of this HN and structurally similar attachment proteins of other members of the paramyxoviridae family were undefined. To define these linkages, disulfide-linked peptides were produced by peptic digestion of pu...

The sequences of the capsular biosynthetic (cps) loci of 90 serotypes of Streptococcus pneumoniae have recently been determined. Bioinformatic procedures were used to predict the general functions of 1,973 of the 1,999 gene products and to identify proteins within the same homology group, Pfam family, and CAZy glycosyltransferase family. Correlating cps gene content with the 54 known capsular p...

BACKGROUND Increasing access to health and social services through service-integration approaches may provide a direct and sustainable way to improve health and social outcomes in low-income families. METHODS We did a community-based randomized trial evaluating the effects of two service-integration practices (healthy family lifestyle and recreational activities for children) among low-income...

Several synthetic 2'-O-methyl-RNA oligomers and their derivatives have been evaluated for inhibitory effect against HIV-induced cytopathic effect and expression of the virus specific antigen in cultured MT-4 cells. In this study, oligo(2'-O-methyl)ribonucleoside phosphorothioates showed a potent inhibitory activity with size dependency (25-mer showed it at 1 microM), but by contrast both 2'-O-m...