نتایج جستجو برای: linked lymphoproliferative disease
تعداد نتایج: 1683373 فیلتر نتایج به سال:
immunohistochemistry.Human turbinates were obtained after turbinectomy from 6 patients with nasal obstruction refractory to medical therapy. Total RNA was isolated from human nasal mucosa, and CysLT2 receptor mRNA was detected in these tissues by using reverse transcriptase-PCR analysis. To identify the cells expressing CysLT2 receptor protein, double immunostaining was performed using anti-Cys...
X-linked lymphoproliferative disease (XLP) is a rare immune disorder commonly triggered by infection with Epstein-Barr virus. Major disease manifestations include fatal acute infectious mononucleosis, B-cell lymphoma, and progressive dys-gammaglobulinemia. SAP/SH2D1A, the product of the gene mutated in XLP, is a small protein that comprises a single SH2 domain and a short tail of 26 amino acids...
Germline mutation of the linker for activation of T cells (LAT) gene at the phospholipase C-gamma1 (PLC-gamma1)-binding site leads to a fatal lymphoproliferative disease in mice. The hyperactivated T cells that develop in these mice have defective T-cell antigen receptor (TCR)-induced calcium flux but enhanced mitogen-activated protein kinase (MAPK) activation. We used genetic analysis to inves...
introduction: castleman's disease is a rare lymphoproliferative disorder which may be confused with other causes of lymphadenopathy. case report: here we report a case of unicentric castleman's disease presenting with cervical lymphadenopathy. the patient was treated with complete surgical excision of lesion and was disease free at the time of reporting this article. this case has bee...
a patient with malignant lymphoma who developed rheumatoid arthritis and facial edema resembling scleredema of buschke is described. pifall s in the clinical diagnosis of this unusual event are stressed. a possiblerelationship between diseases is considered. lymphosarcoma ... immunological disorders and lymphoproliferative disease is considreved
X-linked lymphoproliferative disease (XLP1) is a rare immunodeficiency characterized by severe immune dysregulation and caused by mutations in the SH2D1A/SAP gene. Clinical manifestations are varied and include hemophagocytic lymphohistiocytosis (HLH), lymphoma and dysgammaglobulinemia, often triggered by Epstein-Barr virus infection. Historical data published before improved treatment regimens...
Patients with mutations in Fas develop autoimmune lymphoproliferative disease (ALPS), while their family members with similar mutations are often normal, thereby suggesting that additional factors may play a role in the development of ALPS. In the current study, we tested the role of CD44 in the development of lymphoproliferative disease by generating CD44(-/-)/Fas(-/-) mice, which failed to ex...
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