Abstract Lipid droplets are important storages in fungal conidia and can be used by plant pathogenic fungi for infection. However, the regulatory mechanism of lipid formation utilization during development infection largely unknown. Here, Magnaporthe oryzae , we identified a droplet-associated protein Nem1 that played key role biogenesis utilization. was highly expressed conidia, but lowly appr...

Abstract Host lipid metabolism and viral responses are intimately connected. However, the process by which acquired immune systems adapts to meet demands, whether or not metabolic rewiring confers a selective advantage host immunity, remains unclear. Here we show that infection attenuates expression of genes related in murine CD4 + T cells, turn increases antiviral genes. Inhibition fatty acid ...

The effect of acetic acid on hepatic lipid metabolism in ruminants differs significantly from that in monogastric animals. Therefore, the aim of this study was to investigate the regulation mechanism of acetic acid on the hepatic lipid metabolism in dairy cows. The AMP-activated protein kinase (AMPK) signaling pathway plays a key role in regulating hepatic lipid metabolism. In vitro, bovine hep...

Oxidative stress interferes with hepatic lipid metabolism at various levels ranging from benign lipid storage to so-called second hit of inflammation activation. Isoquercitrin (IQ) is widely present flavonoid but its effects on hepatic lipid metabolism remain unknown. We used free fatty acids (FFA) induced lipid overload and oxidative stress model in two types of liver cells and measured cell v...

Glutathione is an important antioxidant that plays role in myocardial remodeling. However, the exact mechanisms underlying effects of glutathione on heart failure are elusive. This study aimed to investigate treatment based network pharmacology technology. The gene expression profiles were downloaded from Gene Expression Omnibus database (GSE133054). Differentially expressed genes identified by...