A therapeutic aptamer-lipid-poly(lactide-co-glycolic acid) hybrid nanoparticle-based drug delivery system was prepared and characterized. This system can co-deliver two different drugs with distinct solubility and different anticancer mechanisms to target cancer cells with high specificity and efficiency.

Biosynthesis A cell-free membrane protein synthesis system (CFMPS) with natural or artificial lipid biomembranes is constructed, to effectively synthesize full-length transmembrane proteins by improving the solubility and assisting active structure formation, as described Yuan Lu co-workers in article number 2300575. The CFMPS can be further extended expand toolbox of biosynthesis, paving way f...

Phthalocyanine (Pc) is a type of promising sensitizer molecules for photodynamic therapy (PDT), but its hydrophobicity substantially prevents its applications. In this study, we efficiently encapsulate Pc into poly(N-isopropylacrylamide) (pNIPAM) microgel particles, without or with lipid decoration (i.e., Pc@pNIPAM or Pc@pNIPAM/lipid), to improve its water solubility and prevent aggregation in ...

Lipid raft microdomains were conceived as part of a mechanism for the intracellular trafficking of lipids and lipid-anchored proteins. The raft hypothesis is based on the behavior of defined lipid mixtures in liposomes and other model membranes. Experiments in these well-characterized systems led to operational definitions for lipid rafts in cell membranes. These definitions, detergent solubili...

Introduction The main differences between lipids and other biomolecules (carbohydrates, proteins and nucleic acids) are their solubility in non-polar solvents and structure of long hydrocarbon chains. Based on the physical and chemical properties, eukaryotic and prokaryotic lipids are grouped under eight categories, each of which contains distinct classes, subclasses, subgroups and subsets of l...

Some biochemical characteristics of common carp (Cyprinus carpio) and silver carp (Hypophtalmichthys moltrix) surimi prepared by a conventional washing method and protein isolated using alkaline-acid-aided processes were investigated. Solubility of protein in silver carp and common carp were found to be highest by using the conventional washing method. Decreases in myoglobin and lipid contents ...

A semiautomated procedure is described for the estimation of plasma free fatty acids. The method requires the preliminary preparation of a phospholipid-free plasma lipid extract which is then analyzed automatically by a colorimetric procedure based on the solubility of copper soaps in chloroform, with subsequent complexing of the copper with diethyldithiocarbamate and measurement of the extinct...

Rosuvastatin is a lipid lowering agent, which has low solubility and low bioavailability of 20% with oral administration. Therefore the present study was undertaken to improve solubility and bioavailability of Rosuvastatin by formulating it into Nano structured lipid carriers (NLCs) by using stearic acid and Compritol ATO 888 as solid-lipid, Oleic acid as liquid-lipid and Poloxamer 188 as a sur...

Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. The aim of this study was to investigate the potential of cubosomes as lipid nanocarrier to improve the solubility and sustained action of Glimepiride. Glimepiride is one of the third generation sulfonylureas used for treatment of type 2 diabetes. The rationale of this study was to...

Over the past century, phytochemical and phyto pharmacological sciences established the compositions that are biological active and health promoting. Most of the biologically active constituents of plants are polar or water soluble molecules. However, water soluble phyto-constituents (like flavonoids, tannins, terpenoids, etc.) are poorly absorbed either due to their large molecular size which ...