Chemical genomics is a promising new technology for studying gene functions in the context of living organisms or cell systems. It complements existing molecular and genetics tools (e.g. mutagenesis, RNAi) by allowing fine-tunable in vivo modulations of protein functions and cellular processes (Blackwell and Zhao, 2003; Austin et al., 2004; Lipinski and Hopkins, 2004). This approach is feasible...

Nipah virus (NiV) caused several outbreaks in Asian countries, including the latest one from Kerala state of India. There is no drug available against NiV till now, despite its urgent requirement. are reports about anti-influenza viral Favipiravir, which has positively affected vitro models. In current work, we have provided a computational screening for inhibitors. Twenty-two designed compound...

In this work the pharmacological study and synthesis of new thiadiazine bearing on triazole which obtained from hippuric acid , indomethacin mefenamic that have carboxylic moiety, Drugs with groups thiocarbohydrazide interacted to produce 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol (1a-c).
 starting products 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol) were treated chloroacetyl chloride final (2...

The prevalence of gout and the adverse effects current synthetic anti-gout drugs call for new natural effective xanthine oxidase (XOD) inhibitors to target this disease. Based on our previous finding that an edible seaweed Pterocladiella capillacea extract inhibits XOD, XOD-inhibitory anti-inflammatory activities were used evaluate potential different P. fractions. Through affinity ultrafiltrat...

Abstract Background The sixteen (16) designed data set of substituted aryl amine-based triazolopyrimidine were docked against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) employing Molegro Virtual Docker (MVD) software and their pharmacokinetic property determined through SwissADME predictor. Results docking studies shows compound D16, 5-((6-methoxy-5-methyl-[1,2,4]triazolo[1,5-...

Kanker adalah penyakit mematikan di seluruh dunia. Salah satu jenis kanker dengan angka kejadian tinggi Indonesia payudara. Secara umum dapat ditangani pembedahan, radioterapi, dan kemoterapi. Namun, ketiga teknik ini menunjukkan berbagai kelemahan efek samping yang merugikan. Bahan alam selanjutnya menjadi alternatif penanganan karena telah terbukti secara empiris dalam penyakit. Michelia alba...

Chemical genomics is a promising new technology for studying gene functions in the context of living organisms or cell systems. It complements existing molecular and genetics tools (e.g. mutagenesis, RNAi) by allowing fine-tunable in vivo modulations of protein functions and cellular processes (Blackwell and Zhao, 2003; Austin et al., 2004; Lipinski and Hopkins, 2004). This approach is feasible...

Candida albicans (C. albicans) is a fungus that causes candidiasis. C. has the enzyme Lanosterol 14- α demethylase. 14-α-demethylase bioactivity in converting lanosterol to ergosterol, special sterol found fungal membranes, which mediates membrane permeability and fluidity. One way treat candidiasis use traditional medicinal plants. Sungkai (Peronema canescens) can be used as an anti-fungal med...

Sir, Dr. S. Haque Nizamie & P.N. Suresh Kumar in their article 'fluoxetine induced extrapyramidal symptoms: Case reports' in Indian Journal of Psychiatry 1998, Vol. 1,No. 1, 87-89 have categorically remarked absence of suicidal ideation in both the cases who had developed pseudoparkinsonism and akathisia while being treated with fluoxetine alone and in combination with heloperidol & lithium. Ak...