Liquid chromatography electrospray ionization mass spectrometry is a very powerful technique that combines the liquid chromatography separation with highly selective and sensitive mass detection, but the ionization process is susceptible to matrix signal suppression. Signal suppression, therefore, presents a challenge in doing quantitative liquid chromatography/mass spectrometry applications. U...

Temperature-Controlled Microchip Liquid Chromatography System Thesis by Victor Chi-Yuan Shih Doctor of Philosophy in Electrical Engineering California Institute of Technology High-performance liquid chromatography (HPLC) is one of the most important analytical tools heavily used in the fields of chemistry, biotechnology, pharmaceutics, and the food industry. The power of liquid chromatography c...

gamma-aminobutyric acid is the main inhibitory amino acid neurotransmitter in several areas of the brain. measurement of gamma-aminobutyric acid in the brain will help elucidate its metabolic rote and diagnostic value. the liquid chromatography (lc) system consisted of a delivery pump. male rats (150-250g) were used in this study. the brain was rapidly removed from decapitated animals. trie chr...