The renal tubular secretion of thiazides and loop diuretics via the organic anion transport system in renal tubules is required for them to reach their principal sites of action. Similarly, acetazolamide, a diuretic clinically administered for glaucoma, is excreted from the kidney by glomerular filtration and tubular secretion. In this study, we investigated the interaction and transport of the...

Single-use bioreactors are commonly used for seeding stainless steel bioreactors or for producing material. The profitability of these equipments has been well demonstrated on more that decade. But few data on its scalability have been published. In 2010-2011, Merck Serono Biodevelopment performed a study in order to evaluate the performance of several disposable bioreactors. As different techn...

the growth rate of stem cells in mobius cellready 3l bioreactor has been studied using comsol multi-physics simulation software in order to find out the best operational parameters for secure cell growth. the bioreactor geometry was defined according to the emd millipore issued information while turbulent and unsteady state solid-liquid 2-phase fluid flow equations were used for modelling the b...

 An equation-oriented approach was developed for steady state flowsheeting of a commercial methanol plant. The loop consists of fixed bed reactor, flash separator, preheater, coolers, and compressor. For steady sate flowsheeting of the plant mathematical model of reactor and other units are needed. Reactor used in loop is a Lurgi type and its configuration is rather complex. Previously reactor ...

Given the rapid progress in the electronics industry, the thermal management of electronics components becomes an important and serious issue. Natural and forced cooling are often deficient. One possibility for heat dissipation for high heat flux is using loop heat pipe. A loop heat pipe (LHP) is a two-phase device with extremely high effective thermal conductivity that utilizes pressure differ...

The mammalian kidney is an organ composed of numerous functional units or nephrons. Beyond the filtering glomerulus of each nephron, various tubular segments with distinct populations of epithelial cells sequentially span the kidney from cortex to medulla. The highly organized folding of the tubules results in a spatial distribution that allows intimate contact between various tubular subsegmen...

Abstract Therapeutic monoclonal antibodies (mAbs) are typically manufactured using mammalian cell cultures in fed‐batch bioreactors, with increasing emphasis on meeting productivity and product quality attribute targets that depend strongly such process variables as nutrient feed rates bioreactor operating conditions. In this article, we identify, categorize, address the challenges of achieving...

Mixing has been one of the important parameters in characterizing and designing external air-lift bioreactors for the biological processes that require intensive mixing for mass transfer. In this study, pH tracer method was employed to characterize the mixing quality of a three-phase laboratory-scale external-loop air-lift bioreactor (EALR) used for cultivation of a pelletized filamentous funga...