A novel solid phase extractor for preconcentration of cadmium at ng L−1 levels has been developed. Cadmium ions were retained on a column packed with sulfur powder modified with 2-mercaptobenzothiazole (2-MBT) in the medium of 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim]+PF6−) ionic liquid. The presence of ionic liquid during modification of sulfur enhanced the retention of cadmium i...

In this work, two approaches based on Dispersive Liquid-Liquid MicroExtraction (DLLME) and Dispersive Liquid-Liquid MicroExtraction based on Solidification of Floating Organic Drop (DLLME-SFO) were compared for the extraction and preconcentration of crocin from saffron and biological samples. Different DLLME and DLLME-SFO parameters influencing the extraction efficiency were studied and opt...

Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this paper summarizes several new techniques of on-line biological sample processing: solid phase extr...

Alkyl cellosolves include ethylene glycol monomethylether, ethylene glycol monoethylether, ethylene glycol monobuthylether. And their urine metabolites are methoxyacetic acid, ethoxyacetic acid and butoxyacetic acid. The current analytical method for urinary alkoxyacetic acid is liquid-liquid phase extraction. But the liquid-liquid phase extraction method needs a more complex pre-treatment proc...

A simple and sensitive reverse phase high performance liquid chromatographic method for the determination of Pioglitazone (PIO) and Glimepiride (GLM) was developed on a Shimadzu Class vp series HPLC system with a phenomenex C18 column (150x4.6mm, 5μ) using a mobile phase mixture containing methanol and ammonium acetate buffer (pH-3.5) in the ratio of 55: 45. The flow rate was 0.5ml/min and effl...

The simulation of liquid-liquid extraction columns has been of high interest for the last four decades. The well-known procedure is to solve drop-population balances. This approach reaches its limits if the additional influences like reactions shall be included in the simulation and can be solved only with extremely high mathematical effort. ReDrop (Representative Drops) is an alternative way t...

A simple, selective and accurate reversed-phase high pressure liquid chromatogaphic method with UV detection at 274 nm has been developed for the determination of famotidine in human plasma. The procedure employed ranitidine as an internal standard (IS). A good chromatographic separation between famotidine, internal standard and interfering endogenous peaks was achieved using a a C18 column and...

Recent increased demand for stingless bee honey in Malaysia have stimulated alternative methods to increase honey yields by using plastic cups as artificial honey pots within the beehives. However, honey’s acidity may lead to possible migration of plastic additives, where prolonged consumption may affect body’s physiological responses. This study was carried out to determine the presence of dib...

The bioproduction of 3-methylcatechol from toluene via Pseudomonas putida MC2 was performed in a solid-liquid two-phase partitioning bioreactor with the intent of increasing yield and productivity over a single-phase system. The solid phase consisted of HYTREL, a thermoplastic polymer that was shown to possess superior affinity for the inhibitory 3-methylcatechol compared to other candidate pol...

the kinetics of the potassium thiocyanate transport mediated by dicyclohexyl-18-crown-6 (l) through a bulk liquid membrane is studied experimentally and theoretically. the proposed model is based on the assumption of a pure diffusion of the complex salt [k·l]+scn¯ through the liquid membrane stagnant films at the interfaces. it illustrates the connection between liquid-liquid extraction equilib...