BACKGROUND Exposure to chemotherapeutic agents such as acetaminophen may lead to serious liver injury. Calcium deregulation, angiotensin II production and xanthine oxidase activity are suggested to play mechanistic roles in such injury. OBJECTIVE This study evaluates the possible protective effects of the calcium channel blocker amlodipine, the angiotensin converting enzyme inhibitor lisinopr...

INTRODUCTION Although rare, angioedema has been documented to occur following the administration of angiotensin-Converting Enzyme Inhibitors. Angiotensin-converting enzyme inhibitors are the leading cause of drug induced angioedema. Angiotensin-converting enzyme inhibitors induced angioedema is a class effect that can affect between 0.1% and 0.5% of patients taking the drug. It is rarely docume...

Lisinopril is used to treat hypertension, congestive heart failure and to improve survival after a heart attack. Learn about side effects, interactions and indications. PDR Drug Summaries are concise point-of-care prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their. Identify these contraindicated and dangerous lisinopril oral (P...

Medications are often overlooked as a potential cause of acute pancreatitis. In many cases we rely on postmarketing surveillance of new medications to characterize their adverse effect profile, which might include acute pancreatitis. Whereas estrogen-induced pancreatitis is relatively well-recognized, the association of pancreatitis with the newer agents such as angiotensin-converting enzyme (A...

BACKGROUND Reference-based pricing is a cost-containment policy applied to prescription drugs that are in the same class and deemed to be therapeutically equivalent. Recent reference-based pricing measures have targeted several drug classes, including angiotensin-converting-enzyme (ACE) inhibitors. The objective of this study was to assess whether patients treated for hypertension with various ...

BACKGROUND Treatments that reduce inflammation and cardiovascular disease (CVD) risk among individuals with HIV infection receiving effective antiretroviral therapy (ART) are needed. DESIGN AND METHODS We conducted a 2 × 2 factorial feasibility study of lisinopril (L) (10 mg daily) vs L-placebo in combination with pravastatin (P) (20 mg daily) vs P-placebo among participants receiving ART wit...

The peptide angiotensin-converting enzyme inhibitors captopril and lisinopril are unexpectedly shown to exhibit critical aggregation concentration (CAC) behavior through measurements of surface tension, electrical conductivity, dye probe fluorescence. These three provide similar values for the CAC, there is also evidence from circular dichroism spectroscopy a possible conformational change in p...

Introduction and background The question we shall be addressing concerns the origin of dense sickle cell anaemia red cells (SS cells), a fraction of circulating cells rich in irreversibly sickled cells (ISCs), which are thought to play an important role in the pathophysiology of sickle cell disease. The question of their origin was traditionally formulated in terms of their presumed progressive...