Cell therapy is a promising intervention for treating liver diseases and liver failure. Different animal models of human liver cell therapy have been developed in recent years. Rats and mice are the most commonly used liver failure models. In fact, rodent models of hepatic failure have shown significant improvement in liver function after cell infusion. With the advent of stem-cell technologies...

BACKGROUND & AIMS Circulating tumor DNA (ctDNA) carrying tumor-specific sequence alterations has been found in the cell-free fraction of blood. Liver cancer tumor specimens are difficult to obtain, and noninvasive methods are required to assess cancer progression and characterize underlying genomic features. METHODS We analyzed 46 patients with hepatocellular carcinoma who underwent hepatecto...

Background. Only a few biomarkers based on metabolic parameters for evaluating liver fibrosis have been reported. The aim of this study was to investigate the relevance of an index obtained from three metabolic variables (glycated albumin: GA, glycated hemoglobin: HbA1c, and branched-chain amino acids to tyrosine ratio: BTR) to the degree of liver fibrosis in hepatitis C virus virus- (HCV-) pos...

BACKGROUND Plasma-derived cell-free tumor DNA (ctDNA) constitutes a potential surrogate for tumor DNA obtained from tissue biopsies. We posit that massively parallel sequencing (MPS) analysis of ctDNA may help define the repertoire of mutations in breast cancer and monitor tumor somatic alterations during the course of targeted therapy. PATIENT AND METHODS A 66-year-old patient presented with...

OBJECTIVES Recently, somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D genes were found to be associated with the pathogenesis of aldosterone-producing adenoma (APA). This study aimed to investigate the prevalence of somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D and examine the correlations between these mutations and the clinical and biochemical characteristics in Korean patien...

BACKGROUND Myocardial performance index (MPI) or Tei index is a Doppler-derived index of combined systolic and diastolic myocardial function, calculated as the sum of isovolumetric relaxation time (IRT) and isovolumetric contraction time (ICT) divided by the ejection time (ET). OBJECTIVE To evaluate the right and left ventricular systolic and diastolic function using MPI in children before an...

oxygen is an essential part of the most important metabolic pathways in aerobic organisms. oxygen delivery is merely dependent on blood, rendering blood loss a devastating event. traumatic pre-hospital liver bleeding is a major cause of early trauma deaths in human and animals, with no established therapeutic method yet. increasing intra-abdominal pressure (iap) has been shown to reduce liver b...

Purpose. To develop a system for assessing liver function in patients with cirrhosis according to magnetic resonance imaging (MRI) gadoxetic acid. Material and Methods. Data from studies of 74 who underwent abdominal MRI intravenous acid (GA) enhancement were analyzed. For statistical analysis the data, two groups formed: group 1 (n = 22) comprised unchanged parenchyma, normal function, benign ...

A new breeding value estimation procedure for mastitis traits has been implemented in the Dutch/Flemish dairy genetic evaluation. This breeding value estimation uses incidences of subclinical mastitis together with five indicator traits derived from test day somatic cell counts to predict the breeding value for resistance against subclinical and clinical mastitis (SCM and CM, resp.). The mastit...