Resolving molecular determinants of mechanical stability of proteins is crucial in the rational design of advanced biomaterials for use in biomedical and nanotechnological applications. Here we present an interdisciplinary study combining bioinformatics screening, steered molecular dynamics simulations, protein engineering, and single-molecule force spectroscopy that explores the mechanical pro...

Steering of needles involves the planning and timely modifying of instrument-tissue force interactions to allow for controlled deflections during the insertion in tissue. In this work, the effect of tip shape on these forces was studied using 10 mm diameter needle tips. Six different tips were selected, including beveled and conical versions, with or without pre-bend or pre-curve. A six-degree-...

The ability to predict the optimal fingertip forces according to object properties before the object is lifted is known as feedforward control, and it is thought to occur due to the formation of internal representations of the object's properties. The control of fingertip forces to objects of different weights has been studied extensively by using a custom-made grip device instrumented with for...

PURPOSE To analyze the load-, force-, and power-velocity relationships and determine the load that optimizes power output on the pull-up exercise. METHODS Eighty-two resistance-trained men (age 26.8 ± 5.0 y; pull-up 1-repetition maximum [1-RM; normalized per kg of body mass] 1.5 ± 0.34) performed 2 repetitions with 4 incremental loads (range 70-100%1-RM) in the pull-up exercise while mean pro...

BACKGROUND Anterior cruciate ligament (ACL) loading during drop landing has been recently studied with a sagittal plane knee model developed by Kernozek and Ragan using mean anatomical and physiological parameters obtained from cadaveric and clinical data. It is unknown how estimates in ACL load may be altered due to variations in anatomical and physiological parameters used from other research...

PURPOSE The ability to develop high levels of muscle power is considered an essential component of success in many sporting activities; however, the optimal load for the development of peak power during training remains controversial. The aim of the present study was to determine the optimal load required to observe peak power output (PPO) during the hang power clean in professional rugby playe...

OBJECTIVE In orthodontic treatment, intrusion movement of maxillary incisors is often necessary. Therefore, the objective of this investigation is to evaluate the initial distribution patterns and magnitude of compressive stress in the periodontal ligament (PDL) in a simulation of orthodontic intrusion of maxillary incisors, considering the points of force application. METHODS Anatomic 3D mod...

CONTEXT Force sense (FS), the proprioceptive ability to detect muscle-force generation, has been shown to be impaired in individuals with functional ankle instability (FAI). Fatigue can also impair FS in healthy individuals, but it is unknown how fatigue affects FS in individuals with FAI. OBJECTIVE To assess the effect of fatigue on ankle-eversion force-sense error in individuals with and wi...

R We investigated adaptive neural control of precision grip forces during object lifting. A model is presented that adjusts reactive and anticipatory grip forces to a level just above that needed to stabilize lifted objects in the hand. The model obeys principles of cerebellar structure and function by using slip sensations as error signals to adapt phasic motor commands to tonic force generato...