BACKGROUND The 60(+) members of the mammalian Rab protein family group into subfamilies postulated to share common functionality. The Rab VI subfamily contains 5 Rab proteins, Rab6a/a', Rab6b, Rab6c and Rab41. High-level knockdown of Rab6a/a' has little effect on the tightly organized Golgi ribbon in HeLa cells as seen by fluorescence microscopy. In striking contrast, we found Rab41 was strongl...

BACKGROUND Locking plates transmit load through fixed-angle locking screws instead of relying on plate-to-bone compression. Therefore, locking screws may induce higher stress at the screw-bone interface than that seen with conventional nonlocked plating. This study investigated whether locked plating in osteoporotic diaphyseal bone causes a greater periprosthetic fracture risk than conventional...

OBJECTIVES This article is a systematic review of the published literature about the biomechanics, functional outcomes, and complications of a locked plate as an external fixator in treating tibial fractures. METHODS We searched the PubMed, Ovid Medline, Embase, ScienceDirect, and Cochrane Library databases to retrieve the relevant studies. Studies published in English and Chinese which asses...

A rhodamine 6G dye laser, internally pumped within the extended cavity of an Ar(+)-ion laser, is mode locked when its cavity length is matched to half that of the pump laser: the 5145-A argon laser line is passively mode locked by the combination of the saturable absorption and the lasing action of the dye, which is in turn synchronously pumped and mode locked. Tunable (5650-5950-A) ~10 psec pu...

Superharmonic injection locking is investigated in a new theoretical approach. Low power frequency dividers are designed using injection locked oscillators with cascode transistors. The Rockwell 0:5 m CMOS process is used to design a 3mW injection locked frequency divider in the 1800MHz frequency range. A 200MHz maximum locking range is achieved in simulations. 2SC3302 TOSHIBA NPN transistors a...

This work concerns with the design and analysis of phase locked loops (PLLs). In the last decade a lot of works have been done about the analysis of PLLs. The phase locked loops are analyzed briefly, second order, third order, and fourth order. In practically the design of 1.3 GHz, 1.9V second order PLL is considered. SPICE simulation program results confirm the theory. Key-Words: Phase Locked ...

We report, to the best of our knowledge, the first demonstration of thermally controlled soliton mode-locked frequency comb generation in microresonators. By controlling the electric current through heaters integrated with silicon nitride microresonators, we demonstrate a systematic and repeatable pathway to single- and multi-soliton mode-locked states without adjusting the pump laser wavelengt...

We present analytical considerations of "self-mode-locked" operation in a typical vertical external-cavity surface-emitting laser (VECSEL) cavity geometry by means of Kerr lens action in the semiconductor gain chip. We predict Kerr-lens mode-locked operation for both soft- and hard-apertures placed at the optimal intra-cavity positions. These predictions are experimentally verified in a Kerr-le...