Loratadine is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. The present work was aimed to develop of Loratadine using HPMC E15 LV PREMIUM as film forming polymer, glycerin as a plasticizer and tween 80 as a surfactant. The strips were evaluated for thickness, tensile strength, % elongation, disintegration time and in vitro drug re...

OBJECTIVE The objective of this work encompasses the application of the response surface approach in the development of buccoadhesive pharmaceutical wafers of Loratadine (LOR). METHODS Experiments were performed according to a 3(2) factorial design to evaluate the effects of buccoadhesive polymer, sodium alginate (A), and lactose monohydrate as ingredient, of hydrophilic matrix former (B) on ...

of the evidence on off-label doses of cetirizine for chronic urticaria ( hives) to. If higher than standard doses of antihistamines are to be considered, . Double-blind crossover study of high-dose cetirizine in cholinergic urticaria. Zuberbier T(1), Münzberger C, Haustein U, Trippas E, Burtin B, Mariz SD, Henz BM. Nov 10, 2011 . Urticaria (hives) is a common disorder that often presents with s...

PURPOSE The aim of the study was the development of a simple and rapid analytical procedure for the determination of the most frequently used antihistamine derivatives. METHODS A capillary zone electrophoretic method was developed for the simultaneous separation of loratadine, desloratadine and cetirizine. Efforts were focused primarly on the optimisation of the experimental parameters: buffe...

RATIONALE Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding the inflammatory basis of this condition. OBJECTIVES Our goals were to establish whether epithelial cell and mast cell activation with release of inflammatory mediators occurs during EIB and how histamine and cystein...

The aim of the present work was to assess the feasibility of Acconon MC8-2 EP/NF as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. Modified emulsion-solvent diffusion method was employed for the preparation of microsponges (F1-F9) based on  32 factorial design. The amount of ethyl cellulose (EC) and polyvinyl alcohol (PVA) were selected...

Head: Prof. Dr. Judit Hohmann, Univ. of Szeged, Dept. Of Pharmacognosy Reviewers: Dr. György Stampf Ph.D., Semmelweis Univ., Dept. Of Pharmaceutics Dr. Miklós Vecsernyés Ph.D., Univ. of Debrecen, Dept. of Pharmaceutical Technology Members: Dr. Attila Dévay Ph.D., Univ. of Pécs, Inst. of Pharmaceutical Technology and Biopharmacy Dr. Róbert Gáspár Ph.D., Univ. of Szeged, Dept. of Pharmacodynamics...

In the present study, we have demonstrated that multiple first-generation H1-antagonists caused behavioral and EEG seizures in rats. The epileptogenic property of pyrilamine was more potent than either chlorpheniramine or diphenhydramine. In contrast, the second-generation H1-antagonists, loratadine and ebastine did not induce detectable epileptogenic activity. Intraperitoneal injection of hist...

resolution of binary mixtures of theophylline (theo), montelukast (mkst) and loratadine (lora) with minimum sample pretreatment and without analyte separation has been successfully achieved by multivariate spectrophotometric calibration, together with partial least-squares (pls-1), principal component regression (pcr) and hybrid linear analysis (hla). data of analysis were obtained from uv–vis ...