We overview our recent theoretical predictions and the innovative experimental findings that inspired us concerning the mechanisms by which very low-energy (0.1-2 eV) free electrons attach to DNA and cause strong (ca. 4 eV) covalent bonds to break causing so-called single-strand breaks. Our primary conclusions are that (i) attachment of electrons in the above energy range to base pi* orbitals i...

GEANT4 is a toolkit for simulating the passage of particles though matter, which contains a complete range of functionality including tracking, geometry, physics models, and hits. In this article, an attempt to use GEANT4 Monte Carlo code to watch a double-gap Resistive Plate Chamber's (RPC) response to neutrons is presented. The simulation calculations of the double-gap RPC have been evaluated...

Since its release in 1999, the LHC experiments have been evaluating Geant4 in view of adopting it as a replacement for the obsolescent Geant3 transport MonteCarlo. The ALICE collaboration has decided to perform a detailed physics validation of elementary hadronic processes against experimental data already used in international benchmarks. In one test, proton interactions on different nuclear t...

Geant4 is a Monte Carlo simulation Toolkit, describing the interactions of particles with matter. Geant4 is widely used in radiation physics research, from High Energy Physics, to medical physics and space science, thanks to its sophisticated physics component, coupled with advanced functionality in geometry description. Geant4 is widely used at the Centre for Medical Radiation Physics (CMRP), ...

Monte Carlo simulations are increasingly used in scintigraphic imaging to model imaging systems and to develop and assess tomographic reconstruction algorithms and correction methods for improved image quantitation. GATE (GEANT4 application for tomographic emission) is a new Monte Carlo simulation platform based on GEANT4 dedicated to nuclear imaging applications. This paper describes the GATE ...

The concept of nanodosimetry is based on the assumption that initial damage to cells is related to the number of ionizations (the ionization cluster size) directly produced by single particles within, or in the close vicinity of, short segments of DNA. The ionization cluster-size distribution and other nanodosimetric quantities, however, are not directly measurable in biological targets and our...

Introduction: Integrated radiation therapy - MRI systems are capable of delivering high doses to the target tissues near sensitive organs and achieve better therapeutic results; however, the Applied magnetic fields for imaging, can influence the charged path, change the penetration depth and deflect the particles, laterally, leading to dose distribution variations. Therefore, i...