we aimed to study the mntnhex-2-pyp effect on some markers of lung antioxidant defence system in mice asthma model.the study was carried out on 28 c57b1/6 mice divided into four treatment groups: group 1 - controls; group 2 - injected and inhaled with ovalbumin; group 3 - treated with mntnhex-2-pyp and inhaled with phosphate buffered saline; group 4 - injected with ovalbumin and mntnhex-2-pyp b...

Objective(s): Obstructive sleep apnea (OSA) is confirmed to cause lesions in multiple organs, especially in the lung tissue. Tempol is an antioxidant that has been reported to restrain inflammation and oxidative stress, with its role in OSA-induced lung injury being unclear. This study aimed to investigate the beneficial effect of tempol on chronic intermittent hypoxia (IH)-induced lung injury....

The studies of Harrison and his co-workers (1, 2) have demonstrated that heart failure in humans is associated with changes in the electrolyte composition of the cardiac musculature. The potassium content of hearts from patients dying of heart failure was found to be decreased. A similar change was found in the hearts of dogs receiving toxic doses of digitalis (3). More recent studies have demo...

In a healthy lung, the inside surface of respiratory airways is coated with a thin film of lipids and proteins called lung surfactants (LS) which dynamically alter the surface tension and stabilize airways and reduce the work of breathing. Certain clinical events, such as gastric content aspiration, pneumonia, near-drowning, toxic gas inhalation, or chest/lung trauma will trigger lung surfactan...

Obesity is a risk factor for cancer and cancer-related mortality, however, its role in lung cancer progression remains controversial. This study aimed to assess whether high-fat diet (HFD)-induced obesity promotes lung cancer progression and whether the promotion can be decreased by Kanglaite injection (KLTI). In vivo, HFD-induced overweight or obesity increases the lung carcinoma incidence and...

Photon dose calculation algorithms (such as the pencil beam and collapsed cone, CC) model the attenuation of a primary photon beam in media other than water, by using pathlength scaling based on the relative mass density of the media to water. In this study, we assess if differences in the electron density between the water and media, with different atomic composition, can influence the accurac...

the excess accumulation of water in lung interstitial or alveolar is called pulmonary edema which is caused by factors that upset the normal starling balance in micro-circulation. pulmonary edema disturbs the alveolar gas exchanges which are normally regulated by the respiratory system. mathematical modelling of pulmonary edema may help to predict the lung conditions and the mechanisms involved...

MEASUREMENT OF EXTRAVASCULAR lung water has been a topic of major interest for more than two decades (1, 5, 19). In the recent article by Effros et al. (2), they provide a review of current and past efforts to measure extravascular lung water with thermal and osmotic dilution methods. The authors discuss several of the limitations of these methods, including problems related to early recirculat...

BACKGROUND Vibrio vulnificus inside the body could activate the NF-κB signaling pathway and initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsis associated with acute lung injury. High mobility group protein B1 (HMGB1) is an important late-acting pro-inflammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injury proces...