This note discusses a minor mathematical error and a problematic mathematical assumption in Luria and Delbrück's (1943) classic article on fluctuation analysis. In addition to suggesting remedial measures, the note provides information on the latest development of techniques for estimating mutation rates using data from fluctuation experiments.

A patient with atypical temporal lobe seizures involving violent behavior was found to exhibit the neuropsychological syndrome described by Luria (1966, 1976) as pathognomonic of lesions in the depths of the left temporal lobe. This syndrome, mainly an audioverbal memory defect with relatively intact phonemic hearing, was evident in spite of an intact intellect.

A potential drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs is the ease with which viruses may generate escape mutations. Using a variation of the classic Luria-Delbrück fluctuation assay, we estimated that the spontaneous mutation rate in the artificial microRNA (amiR) target of a plant virus was ca. 6 × 10(-5) per replication event.

The relationship of neuroleptic dose and blood serum levels to performance on the Luria Nebraska Neuropsychological Battery in chronic schizophrenics was assessed. Thirty chronic schizophrenics were individually administered the LNNB and a small sample of blood was obtained. No significant correlation between neuroleptic serum levels and test performance in these subjects was found although dif...

Physico-chemical (Schlesinger, 1933; Northrop, 1938; Kalmanson and Bronfenbrenner, 1939) and biological (Ellis and Delbriick, 1939) studies of bacterial viruses (bacteriophages) in the last few years have led to a revival of interest in this group of viruses, particularly as a material on which one can study under very favorable conditions properties which may be common to all viruses. Ease and...

The Luria Nebraska Neuropsychological Battery (LNNB) was administered on a group of 40 schizophrenic patients, 30 brain damaged subjects and 30 normal controls. The data were analysed using SPSS software. Discriminant function analysis results suggested overall hit rate of 77%. On MANOVA all the clinical scales of the LNNB were found to discriminate significantly amongst the groups. The schizop...